Rabbit anti-Human Cystatin D/CST5  Monoclonal Antibody | anti-CST5 antibody

Rabbit anti Human Cystatin D/CST5  Monoclonal Antibody

Cat. Num. AAA2544016

• Reactivity: Human
• Applications: ELISA
• Synonyms: Cystatin D/CST5 ; Monoclonal Antibody; Rabbit anti Human Cystatin D/CST5 Monoclonal Antibody; anti-CST5 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 142

• Applicable Applications for anti-CST5 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human CST5. The detection limit for Human CST5 is approximately 0.0195 ng/well.
• Immunogen: Recombinant Human Cystatin D/CST5 protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-CST5 antibody

Cystatins are natural inhibitors of papain-like (family C1) and legumain-related (family C13) cysteine peptidases. The mammalian cystatin superfamily members are of three major types, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. As a member of type 2 cystatin, cystatin D is a single-domain protein and also has cysteine residues that form disulfide bridges. In contrast with the wider distribution of all the other family 2 cystatins, cystatin D is tissue-restricted expressed and has been found only in saliva and tears. and meanwhile, it displays an inhibition profile with a preferential inhibition on cathepsin S, H, L. Although the exact functions are largely unknown, it has reported that cystatin D is involved in the inhibition of virus replication and apoptosis.

NCBI and Uniprot Product Information

• NCBI GI #: 398711
• NCBI GeneID: 1473
• UniProt Accession #: P28325; Q5JRF5; Q9UCA0
• Molecular Weight: 16,080 Da
• NCBI Official Full Name: cystatin D
• NCBI Official Synonym Full Names: cystatin D
• NCBI Official Symbol: CST5
• NCBI Protein Information: cystatin-D
• UniProt Protein Name: Cystatin-D
• Protein Family: Cystatin
• UniProt Gene Name: CST5
• UniProt Entry Name: CYTD_HUMAN

NCBI Description

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein found in saliva and tears. The encoded protein may play a protective role against proteinases present in the oral cavity. [provided by RefSeq, Jul 2008]

Uniprot Description

CST5: Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B. Belongs to the cystatin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20p11.21

Cellular Component: extracellular region; extracellular space

Molecular Function: cysteine protease inhibitor activity; protease binding; protein binding