SDS-PAGE
MOG recombinant protein
Recombinant Mouse MOG (aa30-149) Protein (His tag)
Gene Names
Mog; B230317G11Rik
Purity
>97 % as determined by SDS-PAGE
Synonyms
MOG; Recombinant Mouse MOG (aa30-149) Protein (His tag); B230317G11Rik; MOG recombinant protein
Host
E Coli
Purity/Purification
>97 % as determined by SDS-PAGE
Form/Format
Lyophilized powder from sterile PBS, pH 5.4, 5% Trehalose, 5% Mannitol, 0.01 % Tween-80
Sequence
Gly 29-Thr 156
Sequence Length
247
Application Notes
The recombinant mouse MOG comprises 138 amino acids and migrates as an approximately 16 kDa band as predicted in SDS-PAGE under reducing conditions.
Species
Mouse
Tag
C-His
Reconstitution
We recommend that the vial be centrifuged to opening to bring the contents tothe bottom. Do not mix by vortex.
It is recommended that sterile water be added to the vial to prepare a stock solutionof 0.15mg/mL. Concentration is measured by UV-Vis.
It is recommended that sterile water be added to the vial to prepare a stock solutionof 0.15mg/mL. Concentration is measured by UV-Vis.
Preparation and Storage
Lyophilized proteins are stable for up to 12 months when stored at -20°C to -80°C.
Reconstituted protein solution can be stored at 4-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Reconstituted protein solution can be stored at 4-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
SDS-PAGE
SDS-PAGE
Related Product Information for MOG recombinant protein
Myelin oligodendrocyte glycoprotein (MOG) is a transmembrane protein belonging to immunoglobulin superfamily, and contains an Ig-like domain followed by two potential membrane-spanning regions. MOG is expressed only in the CNS with very low content (approximately 0.1% total proteins) in oligodendrogliocyte membrane. Three possible functions for MOG were suggested: (a) a cellular adhesive molecule, (b) a regulator of oligodendrocyte microtubule stability, and (c) a mediator of interactions between myelin and the immune system, in particular, the complement cascade. A direct interaction might exist between the membrane-associated regions of MOG and the myelin-specific glycolipid galactocerebroside (Gal-C), and such an interaction may have important consequences regarding the membrane topology and function of both molecules. It is considered that MOG is an autoantigen capable to produce a demyelinating multiple sclerosis-like disease in experimental animals.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Molecular Mass: 16 kDa
AP Molecular Mass: 16 kDa
AP Molecular Mass: 16 kDa
NCBI Official Full Name
myelin-oligodendrocyte glycoprotein
NCBI Official Synonym Full Names
myelin oligodendrocyte glycoprotein
NCBI Official Symbol
Mog
NCBI Official Synonym Symbols
B230317G11Rik
NCBI Protein Information
myelin-oligodendrocyte glycoprotein
UniProt Protein Name
Myelin-oligodendrocyte glycoprotein
Protein Family
UniProt Gene Name
Mog
Uniprot Description
MOG: Mediates homophilic cell-cell adhesion. Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell- cell communication. Defects in MOG are the cause of narcolepsy type 7 (NRCLP7). Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. Belongs to the immunoglobulin superfamily. BTN/MOG family. 10 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 17 B1|17 19.16 cM
Cellular Component: cell surface; lipid raft; myelin sheath
Research Articles on MOG
Similar Products
Product Notes
The MOG mog (Catalog #AAA2546681) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The recombinant mouse MOG comprises 138 amino acids and migrates as an approximately 16 kDa band as predicted in SDS-PAGE under reducing conditions. Researchers should empirically determine the suitability of the MOG mog for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Gly 29-Thr 156. It is sometimes possible for the material contained within the vial of "MOG, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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