CLDN11 / Claudin-11 Recombinant Protein | CLDN11 recombinant protein

Recombinant Human CLDN11 / Claudin-11 Protein (Fc tag)

Cat. Num. AAA2545440

• Gene Names: CLDN11; OSP; OTM
• Purity: >90 % as determined by reducing SDS-PAGE.
• Synonyms: CLDN11 / Claudin-11; Recombinant Human CLDN11 / Claudin-11 Protein (Fc tag); OSP; OTM; CLDN11 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >90 % as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from sterile PBS, pH 7.4, 5% Trehalose, 5% Mannitol, 0.01% Tween-80.
• Sequence: Val23-Arg82

• Species: Human
• Tag: N-Fc
• Endotoxin: < 1.0 EU per ug as determined by the LAL method.
• Reconstitution: We recommend that the vial be centrifuged to opening to bring the contents to the bottom. Do not mix by vortex. It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25mg/mL. Concentration is measured by UV-Vis.
• Preparation and Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7? for 2-7 days.; Aliquots of reconstituted samples are stable at < -20°C for 3 months.

SDS-PAGE

Related Product Information for CLDN11 recombinant protein

Claudin-11, also known as CLDN11, belongs to the group of claudins. Claudins are integral membrane proteins andcomponents of tight junction strands. Tight junction strands function as a physical barrier to prevent solutes and waterfrom passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical rolesin maintaining cell polarity and signal transductions.Claudin-11 is a tight junction associated protein and is a majorcomponent of central nervous system (CNS) myelin that is necessary for normal CNS function. Human blood-testisbarrier disruption is related to a dysfunction of CLDN11 gene. It plays an important role in regulating proliferation andmigration of oligodendrocytes.

NCBI and Uniprot Product Information

• NCBI GI #: 10938016
• NCBI GeneID: 5010
• NCBI GenBank Nucleotide #: NM_005602.5
• UniProt Accession #: O75508; Q5U0P3; B2R7C1; D3DNQ5
• Molecular Weight: Mol_Mass: 33.2 kDa; AP_Mol_Mass: 37 kDa
• NCBI Official Full Name: claudin-11 isoform 1
• NCBI Official Synonym Full Names: claudin 11
• NCBI Official Symbol: CLDN11
• NCBI Official Synonym Symbols: OSP; OTM
• NCBI Protein Information: claudin-11
• UniProt Protein Name: Claudin-11
• Protein Family: Claudin
• UniProt Gene Name: CLDN11
• UniProt Synonym Gene Names: OSP; OTM

NCBI Description

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Aug 2010]

Uniprot Description

Claudin-11: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Belongs to the claudin family.

Protein type: Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3q26.2

Cellular Component: tight junction

Molecular Function: identical protein binding

Biological Process: calcium-independent cell-cell adhesion