ILT3 Recombinant Protein | LILRB4 recombinant protein

ILT3 Protein, Mouse, Recombinant (ECD, His Tag)

Cat. Num. AAA8123276

• Gene Names: Lilrb4a; HM18; ILT3; gp49; CD85K; Gp49b; LIR-5; Lilrb4
• Purity: >95% as determined by SDS-PAGE
• Synonyms: ILT3; ILT3 Protein; Mouse; Recombinant (ECD; His Tag); Mouse ILT3 Protein (ECD; leukocyte immunoglobulin like receptor B4; LILRB4 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Lys238

• Species: Mouse
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Gly 24
• Tag: C-His
• Protein Construction: A DNA sequence encoding the mouse LILRB4 (NP_038560.1)(Met1-Lys238) was expressed with a polyhistidine tag at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for LILRB4 recombinant protein

Background: LILRB4 (Leukocyte Immunoglobulin Like Receptor B4) is a Protein Coding gene. This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. LILRB4 is believed to down-regulate activation signals mediated by non-receptor tyrosine kinase cascades through the recruitment of SHP-1. LILRB4 is associated with the pathological processes of various inflammatory diseases. The LILRB4 is a central inhibitory receptor in Uterine dendritic cells (uDCs) that plays essential immune-regulatory roles at the maternal-fetal interface.

NCBI and Uniprot Product Information

• NCBI GI #: 7305097
• NCBI GeneID: 14728
• NCBI Accession #: NP_038560.1
• NCBI GenBank Nucleotide #: NM_013532.3
• UniProt Accession #: Q64281; Q64312
• Molecular Weight: 33,049 Da
• NCBI Official Full Name: leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 1
• NCBI Official Synonym Full Names: leukocyte immunoglobulin-like receptor, subfamily B, member 4A
• NCBI Official Symbol: Lilrb4a
• NCBI Official Synonym Symbols: HM18; ILT3; gp49; CD85K; Gp49b; LIR-5; Lilrb4
• NCBI Protein Information: leukocyte immunoglobulin-like receptor subfamily B member 4
• UniProt Protein Name: Leukocyte immunoglobulin-like receptor subfamily B member 4
• Protein Family: Leukocyte immunoglobulin-like receptor subfamily
• UniProt Gene Name: Lilrb4
• UniProt Synonym Gene Names: Gp49b
• UniProt Entry Name: LIRB4_MOUSE

Uniprot Description

LILRB4: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5- signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Cellular Component: integral to membrane; membrane; plasma membrane

Biological Process: adaptive immune response; immune system process