Molecular Structure
6BIO, inhibitor
6BIO
Purity
98% (TLC: 5% CH3OH3 in CH2Cl2, Rf=0.43); NMR (Conforms)
Synonyms
6BIO; Hypericin; (2'Z; 3'E)-6-Bromoindirubin-3'-oxime; inhibitor
Purity/Purification
98% (TLC: 5% CH3OH3 in CH2Cl2, Rf=0.43); NMR (Conforms)
Form/Format
Purple powder
CAS Number
667463-62-9
Molecular Formula
C16H10BrN3O2
Melting Point
263-265 degree C
Activity
PKC inhibitor
Solubilization
Soluble in DMSO (15 mg/ml); or Ethanol (4 mg/ml, warm)
Preparation and Storage
Store desiccated as supplied at -20 degree C for up to 1 year. Store solutions at -20 degree C for up to 2 months.
Molecular Structure
Molecular Structure
Related Product Information for 6BIO, inhibitor
GSK3 inhibitor
Scientific Background: Potent and selective inhibitor of glycogen synthase kinase-3 (GSK-3) IC50=5 nM (1). The first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells (2). Promotes proliferation in mammalian cardiomyocytes (2). A potent inhibitor of malignant lymphoid cell proliferation (3).
Scientific Background: Potent and selective inhibitor of glycogen synthase kinase-3 (GSK-3) IC50=5 nM (1). The first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells (2). Promotes proliferation in mammalian cardiomyocytes (2). A potent inhibitor of malignant lymphoid cell proliferation (3).
Product Categories/Family for 6BIO, inhibitor
References
1. L Meijer et al. Chem. Biol. 2003 10:1255
2. AS Tseng et al. Chem. Biol. 2006 13:957
3. A Chebel et al. Leuk. Lymphoma 2009 50:2049
2. AS Tseng et al. Chem. Biol. 2006 13:957
3. A Chebel et al. Leuk. Lymphoma 2009 50:2049
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Product Notes
The 6BIO (Catalog #AAA515022) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "6BIO, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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