Structure
Simeprevir, Inhibitor
Simeprevir
Purity
>98% (HPLC)
Synonyms
Simeprevir; TMC-435; TMC435; TMC435350; TMC-435350; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
HCV
Receptor
HCV
Chemical Name
Cyclopenta[c]cyclopropa[g][1, 6]diazacyclotetradecine-12a(1H)-carboxamide, N-(cyclopropylsulfonyl)-2, 3, 3a, 4, 5, 6, 7, 8, 9, 11a, 12, 13, 14, 14a-tetradecahydro-2-[[7-methoxy-8-methyl-2-[4-(1-methylethyl)-2-thiazolyl]-4-quinolinyl]oxy]-5-methyl-4, 14-dioxo-, (2R, 3aR, 1
SMILES
CC1=C(C=CC2=C1N=C(C=C2OC3CC4C(C3)C(=O)N(CCCCC=CC5CC5(NC4=O)C(=O)NS(=O)(=O)C6CC6)C)C7=NC(=CS7)C(C)C)OC
Molecular Formula
C38H47N5O7S2
CAS Number
923604-59-5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Simeprevir, inhibitor
A potent, orally available inhibitor of HCV NS3/4A protease with Ki of 0.36nM, replicon EC50 of 7.8nM; inhibits NS3/4A proteases of genotypes 1a and 1b with Ki of 0.5 and 0.4nM, shows synergistic effect with alpha-Interferon and an NS5B inhibitor in the replicon model and additive with ribavirin; exerts favorable pharmacokinetic profile and antiviral activity in vivo. HCV Infection Approved
Product Categories/Family for Simeprevir, inhibitor
References
1. Raboisson P, et al. Bioorg Med Chem Lett. 2008 Sep 1; 18 (17):4853-8.
2. Lin TI, et al. Antimicrob Agents Chemother. 2009 Apr; 53 (4):1377-85.
3. Lenz O, et al. Antimicrob Agents Chemother. 2010 May; 54 (5):1878-87.
2. Lin TI, et al. Antimicrob Agents Chemother. 2009 Apr; 53 (4):1377-85.
3. Lenz O, et al. Antimicrob Agents Chemother. 2010 May; 54 (5):1878-87.
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Product Notes
The Simeprevir (Catalog #AAA3606612) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Simeprevir, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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