Structure
Danoprevir Biochemical
Danoprevir
Purity
>98% (HPLC)
Synonyms
Danoprevir; ITMN-191; R-7227; RO-5190591; RG-7227; Danoprevir biochemical
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
HCV
Receptor
HCVNS3/4Aprotease
Chemical Name
2H-Isoindole-2-carboxylic acid, 4-fluoro-1, 3-dihydro-, (2R, 6S, 13aS, 14aR, 16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1, 1-dimethylethoxy)carbonyl]amino]-1, 2, 3, 5, 6, 7, 8, 9, 10, 11, 13a, 14, 14a, 15, 16, 16a-hexadecahydro-5, 16-dioxocyclopropa[e]pyrrolo[1, 2-a]
SMILES
O=C(N1CC2=C(C(F)=CC=C2)C1)O[C@@H](C3)C[C@](C(N[C@@](C4)(C(NS(=O)(C5CC5)=O)=O)[C@]4([H])/C=CCCCCCC6NC(OC(C)(C)C)=O)=O)([H])N3C6=O
Molecular Formula
C35H46FN5O9S
CAS Number
850876-88-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Danoprevir biochemical
A potent, highly selective, orally available, peptidomimetic HCV NS3/4A protease inhibitor with IC50 of 0.2-0.4nM (GT1a, 1b, 4, 5 and 6), 1.6nM (GT2b); shows favorable potency profile against multiple HCV genotypes 1-6 and key mutants (replicon GT1b, EC50=1.6nM). HCV Infection Approved
Product Categories/Family for Danoprevir biochemical
References
1. Bae A, et al. Antimicrob Agents Chemother. 2010 Dec; 54 (12):5288-97.
2. Moucari R, et al. Gut. 2010 Dec; 59 (12):1694-8.
3. Jiang Y, et al. J Med Chem. 2014 Mar 13; 57 (5):1753-69.
4. Schaefer CJ, et al. Antimicrob Agents Chemother. 2011 Jul; 55 (7):3125-32.
2. Moucari R, et al. Gut. 2010 Dec; 59 (12):1694-8.
3. Jiang Y, et al. J Med Chem. 2014 Mar 13; 57 (5):1753-69.
4. Schaefer CJ, et al. Antimicrob Agents Chemother. 2011 Jul; 55 (7):3125-32.
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Product Notes
The Danoprevir (Catalog #AAA3606178) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Danoprevir, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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