Structure
Paritaprevir Biochemical
Paritaprevir
Purity
>98% (HPLC)
Synonyms
Paritaprevir; ABT-450; Veruprevir; Paritaprevir biochemical
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
HCV
Receptor
HCV
Chemical Name
Cyclopropa[e]pyrrolo[1, 2-a][1, 4]diazacyclopentadecine-14a(5H)-carboxamide, N-(cyclopropylsulfonyl)-1, 2, 3, 6, 7, 8, 9, 10, 11, 13a, 14, 15, 16, 16a-tetradecahydro-6-[[(5-methyl-2-pyrazinyl)carbonyl]amino]-5, 16-dioxo-2-(6-phenanthridinyloxy)-, (2R, 6S, 12Z, 13aS, 14aR, 16a
SMILES
O=C([C@]([C@]1([H])/C=CCCCCC[C@@H]2NC(C3=NC=C(C)N=C3)=O)(C1)NC([C@@](C[C@@H](OC4=C5C=CC=CC5=C(C=CC=C6)C6=N4)C7)([H])N7C2=O)=O)NS(=O)(C8CC8)=O
Molecular Formula
C40H43N7O7S
CAS Number
1216941-48-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Paritaprevir biochemical
Paritaprevir (ABT-450, Veruprevir) is a potent HCV NS3/4A protease inhibitor with EC50 of 1 and 0.21nM for HCV GT 1a and 1b, respectively; demonstrates in vitro antiviral activity against HCV GT1-4 and GT6 (EC50=0.09 to 19nM), and an EC50 of 0.09nM against GT4a; The combination of paritaprevir, ritonavir, ombitasvir (an NS5A protein inhibitor), and dasabuvir (an NS5B non-nucleoside polymerase inhibitor) with or without RBV has been approved to treat HCV genotype 1 infections. HCV Infection Approved
Product Categories/Family for Paritaprevir biochemical
References
1. Schnell G, et al. Antimicrob Agents Chemother. 2015 Nov; 59 (11):6807-15.
2. Carrion AF, et al. Expert Opin Pharmacother. 2014 Apr; 15 (5):711-6.
3. Zeuzem S, et al. N Engl J Med. 2014 Apr 24; 370 (17):1604-14.
4. Andreone P, et al. Gastroenterology. 2014 Aug; 147 (2):359-365.e1.
2. Carrion AF, et al. Expert Opin Pharmacother. 2014 Apr; 15 (5):711-6.
3. Zeuzem S, et al. N Engl J Med. 2014 Apr 24; 370 (17):1604-14.
4. Andreone P, et al. Gastroenterology. 2014 Aug; 147 (2):359-365.e1.
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Product Notes
The Paritaprevir (Catalog #AAA3600813) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Paritaprevir, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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