Structure
Faldaprevir, Inhibitor
Faldaprevir
Purity
>98% (HPLC)
Synonyms
Faldaprevir; BI 201335; BI201335; BI-201335; inhibitor
Purity/Purification
>98% (HPLC)
Target
HCV
Receptor
HCV
Chemical Name
(1R, 2S)-1-[[(2S, 4R)-4-[8-bromo-7-methoxy-2-[2-(2-methylpropanoylamino)-1, 3-thiazol-4-yl]quinolin-4-yl]oxy-1-[(2S)-2-(cyclopentyloxycarbonylamino)-3, 3-dimethylbutanoyl]pyrrolidine-2-carbonyl]amino]-2 ethenylcyclopropane-1-carboxylic acid
SMILES
O=C([C@]1(NC([C@H]2N(C([C@@H](NC(OC3CCCC3)=O)C(C)(C)C)=O)C[C@H](OC4=CC(C5=CSC(NC(C(C)C)=O)=N5)=NC6=C(Br)C(OC)=CC=C46)C2)=O)[C@H](C=C)C1)O
Molecular Formula
C40H49BrN6O9S
CAS Number
801283-95-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Faldaprevir, inhibitor
A potent, selective noncovalent competitive inhibitor of HCV NS3/4A protease with Ki of 2.6 and 2.0nM for GT1a and 1b NS3-NS4A protease, respectively; also shows Ki of 2 to 230nM for HCV GT2 to 6, potently inhibits HCV RNA replication in vitro of 6.5 and 3.1nM in genotype 1a and 1b replicon assays, respectively; possesses good ADME profile in vitro and pharmacokinetics in vivo. HCV Infection Phase 2 Clinical
Product Categories/Family for Faldaprevir, inhibitor
References
1. Llini s-Brunet M, et al. J Med Chem. 2010 Sep 9; 53 (17):6466-76.
2. White PW, et al. Antimicrob Agents Chemother. 2010 Nov; 54 (11):4611-8.
3. Manns MP, et al. J Hepatol. 2011 Jun; 54 (6):1114-22.
4. Zeuzem S, et al. Gastroenterology. 2011 Dec; 141 (6):2047-55; quiz e14.
2. White PW, et al. Antimicrob Agents Chemother. 2010 Nov; 54 (11):4611-8.
3. Manns MP, et al. J Hepatol. 2011 Jun; 54 (6):1114-22.
4. Zeuzem S, et al. Gastroenterology. 2011 Dec; 141 (6):2047-55; quiz e14.
Similar Products
Product Notes
The Faldaprevir (Catalog #AAA3605997) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Faldaprevir, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
