Structure
VX-222, Inhibitor
VX-222
Purity
>98% (HPLC)
Synonyms
VX-222; VCH-222; Lomibuvir; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=32mg/mL
Target
HCV
Receptor
HCVNS5B1a; HCVNS5B1b
Chemical Name
2-Thiophenecarboxylic acid, 5-(3, 3-dimethyl-1-butyn-1-yl)-3-[(cis-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]
SMILES
CC1CCC(CC1)C(=O)N(C2CCC(CC2)O)C3=C(SC(=C3)C#CC(C)(C)C)C(=O)O
Molecular Formula
C25H35NO4S
CAS Number
1026785-59-0
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for VX-222, inhibitor
A potent and selective, nonnucleoside inhibitor of HCV NS5B polymerase inhibitor with Kd of 17nM; inhibits the 1b/Con1 HCV subgenomic replicon with EC50 of 17nM, the M423I and A486S variants remaine susceptible to VX-222; exhibits non-competitive and selective inhibition in HCV NS5B of genotype 1a and 1b, with IC50 of 0.94 and 1.2uM, respectively; displays fine pharmacokinetic prole in rats and dogs. HCV Infection Phase 2 Discontinued
Product Categories/Family for VX-222, inhibitor
References
1. Yi G, et al. Antimicrob Agents Chemother. 2012 Feb; 56 (2):830-7.
2. Jiang M, et al. Antimicrob Agents Chemother. 2014 Sep; 58 (9):5456-65.
3. Di Bisceglie AM, et al. Eur J Gastroenterol Hepatol. 2014 Jul; 26 (7):761-73.
2. Jiang M, et al. Antimicrob Agents Chemother. 2014 Sep; 58 (9):5456-65.
3. Di Bisceglie AM, et al. Eur J Gastroenterol Hepatol. 2014 Jul; 26 (7):761-73.
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Product Notes
The VX-222 (Catalog #AAA3600130) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "VX-222, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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