Structure
Crizotinib hydrochloride, Inhibitor
Crizotinib hydrochloride
Purity
>98% (HPLC)
Synonyms
Crizotinib hydrochloride; PF-02341066 hydrochloride; PF-2341066 hydrochloride; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=4.6mg/mL
Target
ALK
Receptor
ALK
Chemical Name
2-Pyridinamine, 3-[(1R)-1-(2, 6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-, hydrochloride(1:1)
SMILES
CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N.Cl
Molecular Formula
C21H23Cl3FN5O
CAS Number
1415560-69-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Crizotinib hydrochloride, inhibitor
Crizotinib (PF-02341066; PF-2341066) is a potent, selective, orally bioavailable, ATP-competitive inhibitor of c-Met catalytic activity with Ki of 4nM; displays >1,000-fold selective for the VEGFR2 and PDGFRbeta RTKs, >250-fold selective for IRK and Lck, and ~40- to 60-fold selective for Tie2, TrkA, and TrkB; also inhibits ALK (IC50=24nM), potently inhibits c-Met phosphorylation and c-Met-dependent proliferation, migration, or invasion of human tumor cells in vitro (IC50=5-20nM); shows antitumor efficacy in tumor models at well-tolerated doses in vivo. Lung Cancer Approved
Product Categories/Family for Crizotinib hydrochloride, inhibitor
References
1. Zou HY, et al. Cancer Res. 2007 May 1; 67 (9):4408-17.
2. Christensen JG, et al. Mol Cancer Ther. 2007 Dec; 6 (12 Pt 1):3314-22.
3. Knowles LM, et al. Clin Cancer Res. 2009 Jun 1; 15 (11):3740-50.
2. Christensen JG, et al. Mol Cancer Ther. 2007 Dec; 6 (12 Pt 1):3314-22.
3. Knowles LM, et al. Clin Cancer Res. 2009 Jun 1; 15 (11):3740-50.
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Product Notes
The Crizotinib hydrochloride (Catalog #AAA3601726) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Crizotinib hydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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