Structure
PHA-408, Inhibitor
PHA-408
Purity
>98% (HPLC)
Synonyms
PHA-408; PHA-767408; PHA767408; PHA 408; inhibitor
Purity/Purification
>98% (HPLC)
Target
IkappaB kinase (IKK)
Receptor
IkappaB kinase (IKK)
Chemical Name
8-[[[5-Chloro-2-(4-methyl-1-piperazinyl)-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4, 5-dihydro-1H-benz[g]indazole-3-carboxamide
SMILES
O=C(C1=NN(C2=CC=C(F)C=C2)C3=C1CCC4=CC=C(NC(C5=C(Cl)C=NC(N6CCN(C)CC6)=C5)=O)C=C43)N
Molecular Formula
C29H27ClFN7O2
CAS Number
503555-55-3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for PHA-408, inhibitor
A novel potent, highly selective, ATP-competitive IKK-2 inhibitor with IC50 of 40nM, 350-fold selectivity over IKK-1; inhibits LPS-induces TNF-alpha producton in PBMCs and HWB with IC50 of 20-30nM, prevents IL-1beta-induced IkappaBalpha phosphorylation in RASFs while sparing the JNK and p38 MAPK pathways and has no effect on IKK-2 phosphorylation; demonstrates target-specific anti-inflammatory activities in in vivo model of airway inflammation.
Product Categories/Family for PHA-408, inhibitor
References
1. Mbalaviele G, et al. J Pharmacol Exp Ther. 2009 Apr; 329 (1):14-25.
2. Sommers CD, et al. J Pharmacol Exp Ther. 2009 Aug; 330 (2):377-88.
3. Xie J, et al. Bioorg Med Chem. 2011 Feb 1; 19 (3):1242-55.
2. Sommers CD, et al. J Pharmacol Exp Ther. 2009 Aug; 330 (2):377-88.
3. Xie J, et al. Bioorg Med Chem. 2011 Feb 1; 19 (3):1242-55.
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Product Notes
The PHA-408 (Catalog #AAA3604710) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PHA-408, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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