Structure
mPGES1-IN-17d, Inhibitor
mPGES1-IN-17d
Purity
>98% (HPLC)
Synonyms
mPGES1-IN-17d; inhibitor
Purity/Purification
>98% (HPLC)
Target
PGE synthase
Receptor
PGE synthase
Chemical Name
2-((2-chloro-6-fluorophenyl)amino)-N-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-7, 8-dihydro-1H-[1, 4]dioxino[2', 3':3, 4]benzo[1, 2-d]imidazole-5-carboxamide
SMILES
O=C(NC1=CC(F)=CC(C(F)(F)F)=C1)C2=C(OCCO3)C3=C(N(C)C(NC4=C(Cl)C=CC=C4F)=N5)C5=C2
Molecular Formula
C24H16ClF5N4O3
CAS Number
1469976-70-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for mPGES1-IN-17d, inhibitor
mPGES1-IN-17d is a potent, selective mPGES-1 inhibitor with enzyme IC50 of 8nM, A549 cell IC50 of 16.24nM, human whole blood IC50 of 249.9nM; displays excellent in vitro selectivity over mPGES-2, cPGES, COX1/2, other prostanoid synthases, favorable hERG and CEREP panel profile; shows good efficacy in LPS-induced thermal hyperalgesia pain model; demonstrates good oral pharmacokinetic profiles and good CNS B/P ratio in rat and guinea pig.
Product Categories/Family for mPGES1-IN-17d, inhibitor
References
1. Muthukaman N, et al. Bioorg Med Chem Lett. 2016 Dec 15; 26 (24):5977-5984.
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Product Notes
The mPGES1-IN-17d (Catalog #AAA3602011) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "mPGES1-IN-17d, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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