Structure
SKF-86002, Inhibitor
SKF-86002
Purity
>98% (HPLC)
Synonyms
SKF-86002; SKF86002; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
p38 MAPK
Receptor
p38MAPK
Chemical Name
Imidazo[2, 1-b]thiazole, 6-(4-fluorophenyl)-2, 3-dihydro-5-(4-pyridinyl)
SMILES
FC1=CC=C(C2=C(C3=CC=NC=C3)N4C(SCC4)=N2)C=C1
Molecular Formula
C16H12FN3S
CAS Number
72873-74-6
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for SKF-86002, inhibitor
SKF-86002 is a potent inhibitor of p38 MAPK with IC50 of 0.5-1uM, inhibits LPS-induced IL-1 and TNF-alpha production in human monocyte with IC50 of 1uM; inhibits prostaglandin H2 (PGH2) synthase activity (IC50=120uM) as well as prostanoid production by rat basophilic leukemia (RBL-1) cells (IC50=70uM); blocks superoxide anion production in response to FMLP and reduces adhesion and chemotaxis in response to PAF or FMLP in human neutrophils; also inhibits 5-lipoxygenase- and cyclooxygenase-mediated arachidonic acid metabolism in RBL-1 cells (IC50=10 and 100uM respectively), shows anti-inflammatory in vivo.
Product Categories/Family for SKF-86002, inhibitor
References
1. Griswold DE, et al. Biochem Pharmacol. 1987 Oct 15; 36 (20):3463-70.
2. Nick JA, et al. J Clin Invest. 1997 Mar 1; 99 (5):975-86.
3. Lee JC, et al. Nature. 1994 Dec 22-29; 372 (6508):739-46.
4. Perregaux DG, et al. Mol Pharmacol. 1995 Sep; 48 (3):433-42.
2. Nick JA, et al. J Clin Invest. 1997 Mar 1; 99 (5):975-86.
3. Lee JC, et al. Nature. 1994 Dec 22-29; 372 (6508):739-46.
4. Perregaux DG, et al. Mol Pharmacol. 1995 Sep; 48 (3):433-42.
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Product Notes
The SKF-86002 (Catalog #AAA3605786) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SKF-86002, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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