Structure
SCIO-469, Inhibitor
SCIO-469
Purity
>98% (HPLC)
Synonyms
SCIO-469; Talmapimod; SCIO469; SCIO 469; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
p38 MAPK
Receptor
p38 MAPK
Chemical Name
1H-Indole-3-acetamide, 6-chloro-5-[[(2R, 5S)-4-[(4-fluorophenyl)methyl]-2, 5-dimethyl-1-piperazinyl]carbonyl]-N, N, 1-trimethyl-alpha-oxo
SMILES
CC1CN(C(CN1C(=O)C2=C(C=C3C(=C2)C(=CN3C)C(=O)C(=O)N(C)C)Cl)C)CC4=CC=C(C=C4)F
Molecular Formula
C27H30ClFN4O3
CAS Number
309913-83-5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for SCIO-469, inhibitor
A potent, selective p38alpha MAPK inhibitor with IC50 of 9nM; displays 10-fold selectivity for p38alpha over p38beta, >2,000-fold selectivity over a panel of 20 other kinases, including other MAP kinases; decreases apoptosis in MDS CD34+ progenitors and leads to dose-dependant increases in erythroid and myeloid colony formation; enhances the ability ofmg132 and bortezomib to induce the apoptosis of MM cells, and inhibits tumor growth in vivo. Rheumatoid Arthritis Phase 2 Discontinued
Product Categories/Family for SCIO-469, inhibitor
References
1. Navas TA, et al. Leukemia. 2006 Jun; 20 (6):1017-27.
2. Navas TA, et al. Blood. 2006 Dec 15; 108 (13):4170-7.
3. Hideshima T, et al. Oncogene. 2004 Nov 18; 23 (54):8766-76.
2. Navas TA, et al. Blood. 2006 Dec 15; 108 (13):4170-7.
3. Hideshima T, et al. Oncogene. 2004 Nov 18; 23 (54):8766-76.
Similar Products
Product Notes
The SCIO-469 (Catalog #AAA3603990) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SCIO-469, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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