Structure
PQR309, Inhibitor
PQR309
Purity
>98% (HPLC)
Synonyms
PQR309; Bimiralisib; PQR-309; PQR 309; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
PI3K
Receptor
pPKB; pS6
Chemical Name
2-Pyridinamine, 5-(4, 6-di-4-morpholinyl-1, 3, 5-triazin-2-yl)-4-(trifluoromethyl)
SMILES
C1COCCN1C2=NC(=NC(=N2)C3=CN=C(C=C3C(F)(F)F)N)N4CCOCC4
Molecular Formula
C17H20F3N7O2
CAS Number
1225037-39-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for PQR309, inhibitor
PQR309 (Bimiralisib) is a potent, brain-penetrant, orally bioavailable, pan-class I PI3K/mTOR inhibitor with IC50 of 33, 451, 661, 708 and 89nM for PI3Kalpha, PI3Kdelta, PI3Kbeta, PI3Kgamma and mTOR, respectively; also shows potent activity against PI3Kalpha E542K/E545K/H2047R mutants with IC50 of 63/136/36nM, shows no significant activity for VPS34 and DNA-PK (IC50>8,000nM); inhibits cellular phosphorylation of PKB/Akt on Ser473 and ribosomal S6 on Ser235/236 in A2058 melanoma cells with IC50 of 139 and 205nM, SKOV3 cell growth IC50 is 237nM; demonstrates efficiency in inhibiting proliferation in tumor cell lines and rat xenograft models. Brain Cancer Phase 2 Clinical
Product Categories/Family for PQR309, inhibitor
References
1. Beaufils F, et al. J Med Chem. 2017 Sep 14; 60 (17):7524-7538.
2. Tarantelli C, et al. Clin Cancer Res. 2018 Jan 1; 24 (1):120-129.
2. Tarantelli C, et al. Clin Cancer Res. 2018 Jan 1; 24 (1):120-129.
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Product Notes
The PQR309 (Catalog #AAA3600862) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PQR309, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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