Structure
Niclosamide, Inhibitor
Niclosamide
Purity
>98% (TLC); NMR (Conforms)
Synonyms
Niclosamide; STAT3 Inhibitor; 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide; inhibitor
Purity/Purification
>98% (TLC); NMR (Conforms)
Form/Format
Yellow powder
CAS
50-65-7
Molecular Formula
C13H8Cl2N2O4
Solubility
May be dissolved DMSO (14 mg/ml, warm)
Preparation and Storage
Store as supplied at ambient temperature for up to 3 years. Store solutions at -20 degree C for up to 3 months.
Structure
Structure
Related Product Information for Niclosamide, inhibitor
**COVID-19 RELATION**
Niclosamide is an active chlorinated salicylanilide compound, with anthelmintic and potential antineoplastic activity used to treat tapeworm infections but has a broad spectrum of therapeutic potential. Scientists are investigating niclosamide and how it inhibits CoV replication and viral antigen synthesis by investigating the various mode of actions such as regulating the mTORC1 pathway, members of which may be interacting with SARS-CoV-2 N and Orf8 proteins; and reducing replication of related coronavirus MERS-CoV via SKP2 inhibition.
Reversibly inhibits Mtorc1 signaling and stimulates autophagy (1). Inhibits activation and nuclear translocation of STAT3 selectively over STAT1 and STAT5. Inhibits transcription of STAT3 target genes and induces cell cycle arrest and apoptosis in cells with constitutively active STAT3 (2). Reverses radioresistance in human lung cancer cells and xenografts (3).
Niclosamide is an active chlorinated salicylanilide compound, with anthelmintic and potential antineoplastic activity used to treat tapeworm infections but has a broad spectrum of therapeutic potential. Scientists are investigating niclosamide and how it inhibits CoV replication and viral antigen synthesis by investigating the various mode of actions such as regulating the mTORC1 pathway, members of which may be interacting with SARS-CoV-2 N and Orf8 proteins; and reducing replication of related coronavirus MERS-CoV via SKP2 inhibition.
Reversibly inhibits Mtorc1 signaling and stimulates autophagy (1). Inhibits activation and nuclear translocation of STAT3 selectively over STAT1 and STAT5. Inhibits transcription of STAT3 target genes and induces cell cycle arrest and apoptosis in cells with constitutively active STAT3 (2). Reverses radioresistance in human lung cancer cells and xenografts (3).
Product Categories/Family for Niclosamide, inhibitor
References
1. AD Balgi et al. PloS One 2009 4:e7124. 2. X Ren et al. ACS Med. Chem. Lett. 2010 1:454. 3. Y Shuo et al. Mol. Cancer Ther. 2013 13:606.
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Product Notes
The Niclosamide (Catalog #AAA515726) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Niclosamide, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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