Structure
Losartan Potassium, Inhibitor
Losartan Potassium
Purity
>99% (TLC); NMR (Conforms)
Synonyms
Losartan Potassium; Angiotensin II Receptor Antagonist; 2-Butyl-4-chloro-1-{[2?-(1H-tetrazol-5-yl)(1; 1?-biphenyl)-4-yl]methyl}-1H-imidazole-5-methanol; potassium salt (DUP-753); inhibitor
Purity/Purification
>99% (TLC); NMR (Conforms)
Form/Format
Off-White Powder
CAS
124750-99-8
Molecular Formula
C22H22ClN6O - K
Solubility
May be dissolved in DMSO (45 mg/ml); or Water (45 mg/ml)
Preparation and Storage
Store desiccated as supplied at 4 degree C for up to 2 years. Store solutions at -20 degree C for up to 2 months.
Structure
Structure
Related Product Information for Losartan Potassium, inhibitor
**COVID-19 RELATION**
Losartan potassium is an active, nonpeptide angiotensin II (AII) receptor antagonist, and has high affinity and selectivity against to the AII subtype 1 (AT(1)) receptor. it is currently being used as a treatment option against hypertension. SARS-CoV-2 infects the human cells by its Spike (S) protein binding to the human ACE2 cell receptor. Renin-Angiotensin-Aldosterone System Inhibitors such losartan are being investigated for their unconventional role in inhibiting SARS-CoV-2/ACE2 fusions at the moment as a possible treatment option to solve the COVID-19 crisis.
Non-peptide angiotensin II receptor antagonist (1,2). Clinically useful antihypertensive agent (3). Inhibits collagen I synthesis (4). Induces SIRT1 expression and activity and reduces hepatic injury in a rat reduced-size orthotopic liver transplantation model (5). Displays neuroprotective effects alone with nimesulide against chronic fatigue stress (6). Displays myocardial antifibrotic activity (7).
Losartan potassium is an active, nonpeptide angiotensin II (AII) receptor antagonist, and has high affinity and selectivity against to the AII subtype 1 (AT(1)) receptor. it is currently being used as a treatment option against hypertension. SARS-CoV-2 infects the human cells by its Spike (S) protein binding to the human ACE2 cell receptor. Renin-Angiotensin-Aldosterone System Inhibitors such losartan are being investigated for their unconventional role in inhibiting SARS-CoV-2/ACE2 fusions at the moment as a possible treatment option to solve the COVID-19 crisis.
Non-peptide angiotensin II receptor antagonist (1,2). Clinically useful antihypertensive agent (3). Inhibits collagen I synthesis (4). Induces SIRT1 expression and activity and reduces hepatic injury in a rat reduced-size orthotopic liver transplantation model (5). Displays neuroprotective effects alone with nimesulide against chronic fatigue stress (6). Displays myocardial antifibrotic activity (7).
Product Categories/Family for Losartan Potassium, inhibitor
References
1. Merck 14: 5583. 2. AT Chiu et al. J. Pharmacol. Exp. Ther. 1990 252:711. 3. M McIntyre et al. Pharmacol. Ther. 1997 74:181. 4. B. Diop-Frimpong et al. Proc. Natl. Acad. Sci. USA 2011 108:2909. 5. E Pantazi et al. World J. Gastroenterol. 2015 21:8021. 6. A Kumar et al. Inflammopharmacology 2015 23:291. 7. JL Miguel-Carrasco et al. Sci. Rep. 2017 7:41865.
Similar Products
Product Notes
The Losartan Potassium (Catalog #AAA515725) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Losartan Potassium, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
