Testing Data
Chloroquine phosphate, Inhibitor
Chloroquine phosphate
Purity
>98% (TLC); NMR (conforms)
Synonyms
Chloroquine phosphate; N4-(7-Chloro-4-quinolinyl)-N1; N1-dimethyl-1; 4-pentanediamine; diphosphate; inhibitor
Purity/Purification
>98% (TLC); NMR (conforms)
CAS Registry Number
50-63-5
Molecular Formula
C18H26ClN3-2H3PO4
Preparation and Storage
Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20 degree C for up to 3 months.
Testing Data
Testing Data
Related Product Information for Chloroquine phosphate, inhibitor
**COVID-19 RELATION**
Chloroquine Phosphate is the phosphate salt of chloroquine, a quinoline compound. The compound is used as an effective treatment against malaria caused by Plasmodium falciparum. Researchers are actively investigating this compound against the SARS-CoV-2 and have documented that that chloroquine phosphate may control the infection by promoting a virus-negative conversion and shortening the disease. The molecular studies suggested multiple potential mechanisms employed by the compound, including inhibiting viral endocytosis; limiting inflammatory response, and binding of Sigma 1 receptor to the SARS-CoV-2 Nsp6 protein.**
Antimalarial drug. Inhibits autophagy in a variety of cell lines (1). Induces cell death in breast cancer cell lines and displays antitumor and antimetastatic activity in mouse models of breast cancer (2). Eliminates cancer stem cells via deregulation of Jak2 and DNMT1 (3). Displays synergy when combined with Raf inhibitor, vemurafenib, in brain tumors (4). Cell permeable and active in vivo.
Chloroquine Phosphate is the phosphate salt of chloroquine, a quinoline compound. The compound is used as an effective treatment against malaria caused by Plasmodium falciparum. Researchers are actively investigating this compound against the SARS-CoV-2 and have documented that that chloroquine phosphate may control the infection by promoting a virus-negative conversion and shortening the disease. The molecular studies suggested multiple potential mechanisms employed by the compound, including inhibiting viral endocytosis; limiting inflammatory response, and binding of Sigma 1 receptor to the SARS-CoV-2 Nsp6 protein.**
Antimalarial drug. Inhibits autophagy in a variety of cell lines (1). Induces cell death in breast cancer cell lines and displays antitumor and antimetastatic activity in mouse models of breast cancer (2). Eliminates cancer stem cells via deregulation of Jak2 and DNMT1 (3). Displays synergy when combined with Raf inhibitor, vemurafenib, in brain tumors (4). Cell permeable and active in vivo.
Product Categories/Family for Chloroquine phosphate, inhibitor
References
1. HB Frieboes et al. JOP 2014 15:189
2. PD Jiang et al. Biomed. Pharmacother. 2010 64:609
3. DS Choi et al. Stem Cells. 2014 32:2309
4. JM Mulcahy Levy et al. Cancer Discov. 2014 4:773
2. PD Jiang et al. Biomed. Pharmacother. 2010 64:609
3. DS Choi et al. Stem Cells. 2014 32:2309
4. JM Mulcahy Levy et al. Cancer Discov. 2014 4:773
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Product Notes
The Chloroquine phosphate (Catalog #AAA516357) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Chloroquine phosphate, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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