Testing Data
Verapamil HCl, Inhibitor
Verapamil HCl
Purity
>98% (TLC); NMR (conforms)
Synonyms
Verapamil HCl; alpha-[3-[[2-(3; 4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3; 4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile; hydrochloride; Calcium Channel Blocker; inhibitor
Purity/Purification
>98% (TLC); NMR (conforms)
CAS Registry Number
152-11-4
Molecular Formula
C27H38N2O4-HCl
Solubility
May be dissolved in water (25mg/ml)
Preparation and Storage
Store desiccated as supplied at ambient temperature for up to 3 years. Store solutions at -20 degree C for up to 3 months.
Testing Data
Testing Data
Related Product Information for Verapamil HCl, inhibitor
**COVID-19 RELATION**
Verapamil is a phenylalkylamine calcium channel blocking compound, which inhibits the transmembrane influx of calcium ions into the cells. The inhibitory potential of verapamil halting the replication of many viruses such as influenza A, MARV, Ebola virus has been well documented. Verapamil also targets the Multidrug resistance-associated protein 1 (MRP1), which studies have shown, interacts with the SARS-CoV-2 Orf9c protein. Breaking this link can prove to be a successful therapeutic intervention against the SARSCOV2 virus. **
L-type calcium channel blocker (1). Clinically useful for the treatment of hypertension and coronary artery disease (2). Binds to and inhibits P-glycoprotein and reverses multidrug resistance in multidrug-resistant CHO cells (3,4). Induces autophagy (5).
Verapamil is a phenylalkylamine calcium channel blocking compound, which inhibits the transmembrane influx of calcium ions into the cells. The inhibitory potential of verapamil halting the replication of many viruses such as influenza A, MARV, Ebola virus has been well documented. Verapamil also targets the Multidrug resistance-associated protein 1 (MRP1), which studies have shown, interacts with the SARS-CoV-2 Orf9c protein. Breaking this link can prove to be a successful therapeutic intervention against the SARSCOV2 virus. **
L-type calcium channel blocker (1). Clinically useful for the treatment of hypertension and coronary artery disease (2). Binds to and inhibits P-glycoprotein and reverses multidrug resistance in multidrug-resistant CHO cells (3,4). Induces autophagy (5).
Product Categories/Family for Verapamil HCl, inhibitor
References
1. L Lacinova et al. J. Pharmacol. Exp. Ther. 1995 274:54
2. RN Brogdan and P Benfield Drugs 1996 51:792
3. AR Safa et al. J. Biol. Chem. 1987 262:7884
4. M Chatterjee et al. Cancer Res. 1990 50:2818
5. A Fleming Nat. Chem. Biol. 2011 7:9
2. RN Brogdan and P Benfield Drugs 1996 51:792
3. AR Safa et al. J. Biol. Chem. 1987 262:7884
4. M Chatterjee et al. Cancer Res. 1990 50:2818
5. A Fleming Nat. Chem. Biol. 2011 7:9
Similar Products
Product Notes
The Verapamil HCl (Catalog #AAA516426) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Verapamil HCl, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
