Structure
Hydroxychloroquine, Inhibitor
Hydroxychloroquine
Purity
>98% (TLC); NMR (Conforms)
Synonyms
Hydroxychloroquine; Lysosomotropic agent; 7-Chloro-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinoline; sulfate.; inhibitor
Purity/Purification
>98% (TLC); NMR (Conforms)
Form/Format
White Powder
CAS
747-36-4
Molecular Formula
C18H26ClN3O - H2SO4
Solubility
May be dissolved in Water (40 mg/ml); DMSO (nil)
Preparation and Storage
Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20 degree C for up to 3 months.
Structure
Structure
Related Product Information for Hydroxychloroquine, inhibitor
**COVID-19 RELATION**
Hydroxychloroquine sulfate is a synthetic version of quinolyl and is a disease-modifying anti-rheumatic drug. The compound acts on the novel SARs-Cov-2 through different mechanisms such as altering the pH at the cell surface, hence inhibiting the viral fusion to the cell membrane receptors, inhibiting nucleic acid replication, by inducing glycosylation of viral proteins. these mechanisms ultimately stopping viral replication and viral infection achieving its antiviral effects. Currently, this compound is being scientifically scrutinized globally for its role against the Sars-Cov-2 virus.
A lysosomotropic agent which inhibits autophagy and triggers apoptosis in a variety of cell types (1,2). Augments the anticancer activity of DNA-damaging chemotherapy (3). Anti-inflammatory activity. Decreases cell surface expression of TNFalpha receptors in U937 cells (4). Has been used to treat alopecia successfully (5). Clinically useful antimalaria agent. Cell permeable and active in vivo.
Hydroxychloroquine sulfate is a synthetic version of quinolyl and is a disease-modifying anti-rheumatic drug. The compound acts on the novel SARs-Cov-2 through different mechanisms such as altering the pH at the cell surface, hence inhibiting the viral fusion to the cell membrane receptors, inhibiting nucleic acid replication, by inducing glycosylation of viral proteins. these mechanisms ultimately stopping viral replication and viral infection achieving its antiviral effects. Currently, this compound is being scientifically scrutinized globally for its role against the Sars-Cov-2 virus.
A lysosomotropic agent which inhibits autophagy and triggers apoptosis in a variety of cell types (1,2). Augments the anticancer activity of DNA-damaging chemotherapy (3). Anti-inflammatory activity. Decreases cell surface expression of TNFalpha receptors in U937 cells (4). Has been used to treat alopecia successfully (5). Clinically useful antimalaria agent. Cell permeable and active in vivo.
Product Categories/Family for Hydroxychloroquine, inhibitor
References
1. P Boya et al. Mol. Cell Biol. 2005 25:1025. 2. X Xie et al. PLoS One 2013 8:e55096. 3. Y Pan et al. Clin. Cancer Res. 2011 150:3248. 4. JY Jeong et al. Immunology 2002 105:83. 5. F Stephan et al. J. Am. Acad. Dermatol. 2013 68:1048.
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Product Notes
The Hydroxychloroquine (Catalog #AAA515728) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Hydroxychloroquine, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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