Structure
Camostat Mesilate, Inhibitor
Camostat Mesilate
Purity
>98% (HPLC); NMR (Conforms)
Synonyms
Camostat Mesilate; Serine protease inhibitor; 4-(2-(2-(dimethylamino)-2-oxoethoxy)-2-oxoethyl)phenyl 4-guanidinobenzoate; methanesul-fonic acid salt; FOY-305; Foipan; inhibitor
Purity/Purification
>98% (HPLC); NMR (Conforms)
Form/Format
Off-White Powder
CAS
59721-29-8
Molecular Formula
C20H22N4O5 - CH3SO3H
Solubility
May be dissolved in DMSO (50 mg/ml); or Water (50 mg/ml)
Preparation and Storage
Store desiccated as supplied at -20 degree C for up to 2 years. Store solutions at -20 degree C for up to 1 month.
Structure
Structure
Related Product Information for Camostat Mesilate, inhibitor
**COVID-19 RELATION**
Camostate mesylate is a potent serine protease inhibitor used as a possible treatment against some cancers, minor viral infections, and pancreatitis. SARS-COV-2 depends on a key human transmembrane serine protease enzyme TMPRSS2 for cell entry. Camostat, a known inhibitor of TMPRSS2 has been observed to control infection of the lung cells by blocking the MERS-S, SARS-S and SRAS-2-S entry by selectively inhibiting the TMPRSS2 protein, hence halting the Viral S-TMPRSS2 fusion, which is pivotal for the virus to enter the cells.
A serine protease inhibitor inhibiting plasmin, kallikrein, thrombin as well as trypsin, which attenuates pancreatic fibrosis (1). Reduces weight gain and improves metabol-ism in obese rodent models (2). In clinical use (in Japan) for pancreatitis (3). Inhibits influenza virus replication in human tracheal epithelial cells (4). Reduces infection of Calu-3 lung cells by SARS-CoV-2 (responsible for COVID-19) via inhibition of the serine protease TMPRSS2 required for viral spike protein priming (5).
Camostate mesylate is a potent serine protease inhibitor used as a possible treatment against some cancers, minor viral infections, and pancreatitis. SARS-COV-2 depends on a key human transmembrane serine protease enzyme TMPRSS2 for cell entry. Camostat, a known inhibitor of TMPRSS2 has been observed to control infection of the lung cells by blocking the MERS-S, SARS-S and SRAS-2-S entry by selectively inhibiting the TMPRSS2 protein, hence halting the Viral S-TMPRSS2 fusion, which is pivotal for the virus to enter the cells.
A serine protease inhibitor inhibiting plasmin, kallikrein, thrombin as well as trypsin, which attenuates pancreatic fibrosis (1). Reduces weight gain and improves metabol-ism in obese rodent models (2). In clinical use (in Japan) for pancreatitis (3). Inhibits influenza virus replication in human tracheal epithelial cells (4). Reduces infection of Calu-3 lung cells by SARS-CoV-2 (responsible for COVID-19) via inhibition of the serine protease TMPRSS2 required for viral spike protein priming (5).
Product Categories/Family for Camostat Mesilate, inhibitor
References
1. J Gibo et al. Lab. Invest. 2005 85:75. 2. K Albarazanji et al. Am. J. Physiol. Gastrointest. Liver Physiol. 2019 316:G653. 3. M Ueda et al. Nephron 2015 129:223. 4. M Yamaya et al. Pulm. Pharmacol. Ther. 2015 33:66. 5. M Hoffmann et al. Cell 2020 181:1.
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Product Notes
The Camostat Mesilate (Catalog #AAA515727) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Camostat Mesilate, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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