Structure
Allitinib Biochemical
Allitinib
Purity
>98%
Synonyms
Allitinib; AST-1306; N-(4-(3-Chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)acrylamide; N-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]prop-2-enamide; Allitinib biochemical
Specificity
An irreversible ErbB2 and EGFR inhibitor
Purity/Purification
>98%
Form/Format
Solid
Solubilities
~20mg/ml in DMSO
Molecular Formula
C??H??ClFN?O?
InChi
InChI=1S/C24H18ClFN4O2/c1-2-23(31)29-17-6-8-21-19(11-17)24(28-14-27-21)30-18-7-9-22(20(25)12-18)32-13-15-4-3-5-16(26)10-15/h2-12; 14H; 1; 13H2; (H; 29; 31)(H; 27; 28; 30)
InChi Key
MVZGYPSXNDCANY-UHFFFAOYSA-N
SMILES
C=CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=C(C=C3)OCC4=CC(=CC=C4)F)Cl
CAS Number
897383-62-9
MDL Number
MFCD17169993
PubChem CID
24739943
Preparation and Storage
Store at -20 degree C
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Shelf Life: Est.~36 months
Country of Origin: USA
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Shelf Life: Est.~36 months
Country of Origin: USA
Structure
Structure
Related Product Information for Allitinib biochemical
Allitinib is a novel anilino-quinazoline compound that inhibits ErbB tyrosine kinases: epidermal growth factor receptor (EGFR) and ErbB2. It inhibits EGFR and ErbB2 with IC50 values of 0.5nM and 3nM in cell-free assays. It inhibits the phosphorylation of EGFR and ErbB2 and downstream signaling in human cancer cells. It potently inhibits cell lines expressing high levels of ErbB2 such as Calu-3 lung adenocarcinoma and BT474 breast cancer cells with IC50 values of 0.23uM and 0.97uM respectively. It inhibits tumor growth in the SK-OV-3 xenograft model.
Product Categories/Family for Allitinib biochemical
References
https://pubchem.ncbi.nlm.nih.gov/compound/24739943
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Product Notes
The Allitinib (Catalog #AAA8400443) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Allitinib, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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