Structure
(Structure of L1315-50.)
Lapatinib, Di-p-Toluenesulfonate Salt, Inhibitor
Lapatinib, Di-p-Toluenesulfonate Salt (N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine Ditosylate, Lapatinib Ditosylate, Tykerb, GW-572016, Tyverb)
Purity
Highly Purified~99%
Synonyms
Lapatinib; Di-p-Toluenesulfonate Salt; Di-p-Toluenesulfonate Salt (N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine Ditosylate; Lapatinib Ditosylate; Tykerb; GW-572016; Tyverb); inhibitor
Purity/Purification
Highly Purified
~99%
~99%
Form/Format
Supplied as a yellow powder.
CAS Number
388082-78-8
Molecular Formula
C29H26ClFN4O4S• 2C7H8O3S
Solubility
Soluble in DMSO at 200mg/ml; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 1-10uM; buffers, serum, or other additives may increase or decrease the aqueous solubility.
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 6 months.
Structure
(Structure of L1315-50.)
Structure
(Structure of L1315-50.)
Related Product Information for Lapatinib, Di-p-Toluenesulfonate Salt, inhibitor
Lapatinib inhibits both epidermal growth factor receptor (EGFR) and HER2/neu (ErbB-2) tyrosine kinases by binding to the intracellular phosphorylation domain, preventing receptor autophosphorylation. The exact site of binding has currently not been confirmed. It appears to arrest the development of breast cancer in some patients with metastatic, treatment-refractory disease.
Product Categories/Family for Lapatinib, Di-p-Toluenesulfonate Salt, inhibitor
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Product Notes
The Lapatinib, Di-p-Toluenesulfonate Salt (Catalog #AAA655423) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Lapatinib, Di-p-Toluenesulfonate Salt, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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