IPI-549, Inhibitor
IPI-549
Purity
>98% (HPLC)
Synonyms
IPI-549; IPI549; IPI 549; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 15mg/mL
Target
PI3K
Receptor
PI3K
Chemical Name
Pyrazolo[1, 5-a]pyrimidine-3-carboxamide, 2-amino-N-[(1S)-1-[1, 2-dihydro-8-[2-(1-methyl-1H-pyrazol-4-yl)ethynyl]-1-oxo-2-phenyl-3-isoquinolinyl]ethyl]
SMILES
O=C1N(C2=CC=CC=C2)C([C@@H](NC(C3=C(N=CC=C4)N4N=C3N)=O)C)=CC5=CC=CC(C#CC6=CN(C)N=C6)=C51
Molecular Formula
C30H24N8O2
CAS Number
1693758-51-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Related Product Information for IPI-549, inhibitor
IPI-549 (IPI549) is apotent, highly selective, orally active inhibitor of PI3Kgamma with IC50 of 16nM, displays >100-fold selectivity over other lipid and protein kinases (PI3Kalpha IC50=3.2uM, PI3Kbeta IC50=3.5uM, PI3Kdelta IC50>8.4uM); demonstrates excellent PI3Kgamma potency (IC50=1.2nM) and selectivity against other Class I PI3K isoforms (>146-fold) in cellular phospho-AKT assays, dose dependently inhibits PI3Kgamma dependent bone marrow-derived macrophage (BMDM) migration; demonstrates favorable pharmacokinetic properties and robust inhibition of PI3K-gamma mediated neutrophil migration in vivo. Solid Tumors Phase 1 Clinical
Product Categories/Family for IPI-549, inhibitor
References
1. Evans CA, et al. ACS Med Chem Lett. 2016 Jul 22; 7 (9):862-7.
2. De Henau O, et al. Nature. 2016 Nov 17; 539 (7629):443-447.
2. De Henau O, et al. Nature. 2016 Nov 17; 539 (7629):443-447.
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Product Notes
The IPI-549 (Catalog #AAA3602582) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "IPI-549, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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