Structure
Fingolimod, Inhibitor
Fingolimod
Purity
99.76%
Synonyms
Fingolimod; FTY-720A; FTY-720; inhibitor
Purity/Purification
99.76%
Form/Format
Solid. Powder
Solubility
DMSO: 66.67mg/mL (216.83mM) Need ultrasonic
Methanol: 30mg/mL (97.57mM) Need ultrasonic
Ethanol: 7.69mg/mL (25.01mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Methanol: 30mg/mL (97.57mM) Need ultrasonic
Ethanol: 7.69mg/mL (25.01mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C19H33NO2
SMILES
CCCCCCCCc1ccc(CCC(N)(CO)CO)cc1
CAS Number
162359-55-9
Target & IC50
sphingosine 1-phosphate (S1P): ic50 0.033nM
Cell Research
Sciatic nerve crush was performed in wildtype C57BL/6, in immunodeficient Rag1 (-/-) and Foxn1 (-/-) mice. Analyses were based on walking track analysis and electrophysiology, histology, and cAMP formation. Quantification of different LPA species was performed by liquid chromatography coupled to tandem mass spectrometry. Furthermore, functional consequences of autotaxin inhibition by the specific inhibitor PF-8380 and the impact of fingolimod on early cytokine release in the injured sciatic nerve were investigated[1].
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for Fingolimod, inhibitor
Fingolimod is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033nM in K562 and NK cells).
Product Categories/Family for Fingolimod, inhibitor
References
Szepanowski, Fabian, Derksen, Angelika, Steiner, Irina,et al. Fingolimod promotes peripheral nerve regeneration via modulation of lysophospholipid signaling[J]. Journal of Neuroinflammation, 13(1):143.
Szepanowski, Fabian, Derksen, Angelika, Steiner, Irina,et al. Fingolimod promotes peripheral nerve regeneration via modulation of lysophospholipid signaling[J]. Journal of Neuroinflammation, 13(1):143.
Amelioration of colitis through blocking lymphocytes entry to Peyer's patches by sphingosine-1-phosphate lyase inhibitor[J]. Journal of Gastroenterology & Hepatology, 2018, 33(9).
Amelioration of colitis through blocking lymphocytes entry to Peyer's patches by sphingosine-1-phosphate lyase inhibitor[J]. Journal of Gastroenterology & Hepatology, 2018, 33(9).
Szepanowski, Fabian, Derksen, Angelika, Steiner, Irina,et al. Fingolimod promotes peripheral nerve regeneration via modulation of lysophospholipid signaling[J]. Journal of Neuroinflammation, 13(1):143.
Amelioration of colitis through blocking lymphocytes entry to Peyer's patches by sphingosine-1-phosphate lyase inhibitor[J]. Journal of Gastroenterology & Hepatology, 2018, 33(9).
Amelioration of colitis through blocking lymphocytes entry to Peyer's patches by sphingosine-1-phosphate lyase inhibitor[J]. Journal of Gastroenterology & Hepatology, 2018, 33(9).
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Product Notes
The Fingolimod (Catalog #AAA5758797) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Fingolimod, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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