Testing Data (TD)
FTY720, inhibitor
FTY720 (Fingolimod)
Purity
>99%
Synonyms
FTY720; FTY720 (Fingolimod); inhibitor
Purity/Purification
>99%
Solubility
DMSO
Formula
C19H33NO2.HCl
CAS Number
162359-56-0
Preparation and Storage
Store at -20°C for 2 years.
Testing Data (TD)
Testing Data (TD)
Related Product Information for FTY720, inhibitor
TY720(Fingolimod) is a potent sphingosine-1-phosphate (S1P) receptors agonist with IC50 of 0.137, 10.98 nM for (S)- and (R)- FTY720-phosphate, respectively and reverses the effects of BCR-ABL kinase. It is a novel immunomodulating agent and can sequester lymphocytes in lymph nodes, preventing them from moving to the central nervous system for auto-immune responses in multiple sclerosis and was originally proposed as a anti-rejection medication indicated post-transplantation. 1] It can be phosphorylated by sphingosine kinase and prevents disease in a mouse model of many leuke mias caused by BCR-ABL. It does not directly target the BCR-ABL kinase, but instead activates phosphatase 2A (PP2A) which is a tumor suppressor that is inactivated by BCR-ABL. [2] FTY720(Fingolimod) also mediated antitumor effects in hepatocellular carcinoma (HCC) cells by activating PKC . The three HCC cell lines examined, Hep3B, Huh7, and PLC5, exhibited differential susceptibility to FTY720-mediated suppression of cell viability, with IC50 values of 4.5, 6.3, and 11 ?M, respectively.
Product Categories/Family for FTY720, inhibitor
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Product Notes
The FTY720 (Catalog #AAA8506305) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "FTY720, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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