Structure
Fenebrutinib, Inhibitor
Fenebrutinib
Purity
>98% (HPLC)
Synonyms
Fenebrutinib; RG-7845; GDC-0853; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=23mg/mL
Target
BTK
Receptor
BTK
Chemical Name
2H-Cyclopenta[4, 5]pyrrolo[1, 2-a]pyrazin-1(6H)-one, 2-[1, 6-dihydro-3'-(hydroxymethyl)-1-methyl-5-[[5-[(2S)-2-methyl-4-(3-oxetanyl)-1-piperazinyl]-2-pyridinyl]amino]-6-oxo[3, 4'-bipyridin]-2'-yl]-3, 4, 7, 8-tetrahydro-7, 7-dimethyl
SMILES
CC1CN(CCN1C2=CN=C(C=C2)NC3=CC(=CN(C3=O)C)C4=C(C(=NC=C4)N5CCN6C7=C(CC(C7)(C)C)C=C6C5=O)CO)C8COC8
Molecular Formula
C37H44N8O4
CAS Number
1434048-34-6
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Fenebrutinib, inhibitor
An orally bioavailable, selective, non-covalent and reversible BTK inhibitor with IC50 of 2-9nM; has demonstrated efficacy in pre-clinical autoimmune disease models and is being developed for the treatment of rheumatoid arthritis and lupus, with future development for other autoimmune indications. RheumatoId Arthritis Phase 2 Clinical
Product Categories/Family for Fenebrutinib, inhibitor
References
1. Erickson RI, et al. J Pharmacol Exp Ther. 2017 Jan; 360 (1):226-238.
2. Katsumoto, T. 2016 ACR/ARHP Annual Meeting (2016).
2. Katsumoto, T. 2016 ACR/ARHP Annual Meeting (2016).
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Product Notes
The Fenebrutinib (Catalog #AAA3601845) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Fenebrutinib, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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