Structure
AZD-9056 hydrochloride, Inhibitor
AZD-9056 hydrochloride
Purity
>98% (HPLC)
Synonyms
AZD-9056 hydrochloride; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=34mg/mL
Target
P2X Receptor
Receptor
P2X Receptor
Chemical Name
Benzamide, 2-chloro-5-[3-[(3-hydroxypropyl)amino]propyl]-N-(tricyclo[3.3.1.13, 7]dec-1-ylmethyl)-, hydrochloride(1:1)
SMILES
C1C2CC3CC1CC(C2)(C3)CNC(=O)C4=C(C=CC(=C4)CCCNCCCO)Cl.Cl
Molecular Formula
C24H36Cl2N2O2
CAS Number
345303-91-5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for AZD-9056 hydrochloride, inhibitor
A potent, selective, orally bioavailable P2X7 receptor antagonist; inhibits release of pro-inflammatory mediators from isolated human peripheral monocytes (IL-1beta and IL-18) and human alveolar macrophages (IL-1beta) with IC50 values of 10-13nM; displays >100-fold selectivity and specificity other P2X receptors; also is an inhibitor of BCRP and weakly inhibited BCRP-mediated transport of methotrexate (IC50=92uM); significantly reduces disease severity in the streptococcal cell wall (SCW) model of arthritis. Rheumatoid Arthritis Phase 2 Clinical
Product Categories/Family for AZD-9056 hydrochloride, inhibitor
References
1. Hu H, et al. Int J Mol Med. 2016 Dec; 38 (6):1922-1932.
2. Seeland S, et al. Int J Mol Med. 2016 Dec; 38 (6):1922-1932.
2. Seeland S, et al. Int J Mol Med. 2016 Dec; 38 (6):1922-1932.
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Product Notes
The AZD-9056 hydrochloride (Catalog #AAA3604178) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AZD-9056 hydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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