Structure
GLPG-0634, Inhibitor
GLPG-0634
Purity
>98% (HPLC)
Synonyms
GLPG-0634; Filgotinib; GLPG 0634; GLPG0634; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 6.8mg/mL
Target
JAK
Receptor
JAK1; JAK2; JAK3; Tyk2
Chemical Name
Cyclopropanecarboxamide, N-[5-[4-[(1, 1-dioxido-4-thiomorpholinyl)methyl]phenyl][1, 2, 4]triazolo[1, 5-a]pyridin-2-yl]
SMILES
O=C(C1CC1)NC2=NN3C(C4=CC=C(CN5CCS(CC5)(=O)=O)C=C4)=CC=CC3=N2.
Molecular Formula
C21H23N5O3S
CAS Number
1206161-97-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for GLPG-0634, inhibitor
A potent JAK1/JAK2 inhibitor with IC50 of 10nM/28nM in biochemical assays; less potent for JAK3 and TYK2; reveals a selectivity of 30-fold for JAK1- over JAK2-dependent signaling in cellular and whole blood assays; inhibited Th1 and Th2 differentiation and to a lesser extent the differentiation of Th17 cells in vitro; shows efficacy in the collagen-induced arthritis models and orally active. Rheumatoid Arthritis Phase 3 Clinical
Product Categories/Family for GLPG-0634, inhibitor
References
1. Menet CJ, et al. J Med Chem. 2014 Nov 26; 57 (22):9323-42.
2. Van Rompaey L, et al. J Immunol. 2013 Oct 1; 191 (7):3568-77.
3. Chen H, et al. Sci Rep. 2016 Jul 26; 6:30459.
2. Van Rompaey L, et al. J Immunol. 2013 Oct 1; 191 (7):3568-77.
3. Chen H, et al. Sci Rep. 2016 Jul 26; 6:30459.
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Product Notes
The GLPG-0634 (Catalog #AAA3600752) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "GLPG-0634, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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