Structure
AVL-292 besylate, Inhibitor
AVL-292 besylate
Purity
>98% (HPLC)
Synonyms
AVL-292 besylate; Spebrutinib besylate; CC-292 besylate; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
BTK
Receptor
BTK
Chemical Name
2-Propenamide, N-[3-[[5-fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-, benzenesulfonate(1:1)
SMILES
COCCOC1=CC=C(C=C1)NC2=NC=C(C(=N2)NC3=CC(=CC=C3)NC(=O)C=C)F.C1=CC=C(C=C1)S(=O)(=O)O
Molecular Formula
C28H28FN5O6S
CAS Number
1360053-81-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for AVL-292 besylate, inhibitor
AVL-292 besylate (Spebrutinib, CC-292) is a highly selective, covalent Btk inhibitor with IC50 of <1nM; also less potently inhibits Yes, c-Src, Brk, Lyn, and Fyn with IC50s of 723nM, 1.729uM, 2.43uM, 4.4uM, and 7.15uM, rspectively; shows anti-inflammatory activity in the collagen-induced arthritis model of autoimmune disease; also prevents NRG- and EGF-dependent growth factor-driven resistance to lapatinib in HER2(+) breast cancer cells. Rheumatoid Arthritis Phase 2 Clinical
Product Categories/Family for AVL-292 besylate, inhibitor
References
1. Evans EK, et al. J Pharmacol Exp Ther. 2013 Aug; 346 (2):219-28.
2. Eda H, et al. Leukemia. 2014 Sep; 28 (9):1892-901.
3. Wang X, et al. Mol Cancer Ther. 2016 Sep; 15 (9):2198-208.
2. Eda H, et al. Leukemia. 2014 Sep; 28 (9):1892-901.
3. Wang X, et al. Mol Cancer Ther. 2016 Sep; 15 (9):2198-208.
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Product Notes
The AVL-292 besylate (Catalog #AAA3601478) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AVL-292 besylate, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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