Structure
BMS-986142, Inhibitor
BMS-986142
Purity
>98% (HPLC)
Synonyms
BMS-986142; BMS 986142; BMS986142; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 120mg/mL
Water: Insoluble (<1mg/mL refers to the product slightly soluble or insoluble)
Water: Insoluble (<1mg/mL refers to the product slightly soluble or insoluble)
Target
BTK
Receptor
BTK; TEC; ITK; BLK; TXK; BMX
Chemical Name
6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2, 4-dioxo-1, 2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2, 3, 4, 9-tetrahydro-1H-carbazole-8-carboxamide
SMILES
O=C(C1=CC(F)=[C@]([C@]2=CC=CC(N3C(N(C)C4=C(C=CC=C4F)C3=O)=O)=C2C)C5=C1NC6=C5CC[C@H](C(C)(O)C)C6)N
Molecular Formula
C32H30F2N4O4
CAS Number
1643368-58-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for BMS-986142, inhibitor
BMS-986142 (BMS 986142) is a potent, selective and reversible BTK inhibitor with IC50 of 0.5nM; displays 20-60-fold selectivity over Tec family kinases, >10,000-fold selectivity over JAK2; potently inhibits signaling and functional end points, including calcium flux (IC50=9nM), production of cytokines, proliferation, and surface expression of CD86 (IC50=3-4nM); potently inhibits BCR-stimulated expression of CD69 on B cells in human whole blood with IC50 of 90nM; exhibits excellent in vivo properties and efficacy, and a very desirable tolerability and safety profile. Rheumatoid Arthritis Phase 2 Clinical
Product Categories/Family for BMS-986142, inhibitor
References
1. Watterson SH, et al. J Med Chem. 2016 Oct 13; 59 (19):9173-9200.
2. Lee SK, et al. Eur J Clin Pharmacol. 2017 Jun; 73 (6):689-698.
3. Gillooly KM, et al. PLoS One. 2017 Jul 24; 12 (7):e0181782.
2. Lee SK, et al. Eur J Clin Pharmacol. 2017 Jun; 73 (6):689-698.
3. Gillooly KM, et al. PLoS One. 2017 Jul 24; 12 (7):e0181782.
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Product Notes
The BMS-986142 (Catalog #AAA3602500) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BMS-986142, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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