Structure
EMA401, Inhibitor
EMA401
Purity
>98% (HPLC)
Synonyms
EMA401; EMA 401; EMA-401; Olodanrigan; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=34mg/mL
Target
Angiotensin Receptor
Receptor
angiotensinIIreceptor
Chemical Name
3-Isoquinolinecarboxylic acid, 2-(2, 2-diphenylacetyl)-1, 2, 3, 4-tetrahydro-6-methoxy-5-(phenylmethoxy)-, (3S)
SMILES
COC1=C(C2=C(CN(C(C2)C(=O)O)C(=O)C(C3=CC=CC=C3)C4=CC=CC=C4)C=C1)OCC5=CC=CC=C5
Molecular Formula
C32H29NO5
CAS Number
1316755-16-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for EMA401, inhibitor
EMA401 (Olodanrigan) is a potent, highly selective angiotensin II type 2 receptor (AT2R) antagonist, inhibits capsaicin responses in cultured neurons of human and rat DRG with IC50 of 10nM; EMA401 is a novel peripherally-restricted analgesic, may act on paracrine/autocrine mechanisms at peripheral nerve terminals, or intracrine mechanisms, to reduce neuropathic pain signalling in AngII/NGF/TRPV1-convergent pathways. Pain Phase 2 Clinical
Product Categories/Family for EMA401, inhibitor
References
1. Anand U, et al. Eur J Pain. 2013 Aug; 17 (7):1012-26.
2. Smith MT, et al. Pain Med. 2013 May; 14 (5):692-705.
3. Rice ASC, et al. Lancet. 2014 May 10; 383 (9929):1637-1647.
4. Anand U, et al. Mol Pain. 2015 Jun 26; 11:38.
2. Smith MT, et al. Pain Med. 2013 May; 14 (5):692-705.
3. Rice ASC, et al. Lancet. 2014 May 10; 383 (9929):1637-1647.
4. Anand U, et al. Mol Pain. 2015 Jun 26; 11:38.
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Product Notes
The EMA401 (Catalog #AAA3601283) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "EMA401, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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