Structure
JNJ-18038683 Biochemical
JNJ-18038683
Purity
>98% (HPLC)
Synonyms
JNJ-18038683; JNJ18038683; JNJ-18038683 biochemical
Purity/Purification
>98% (HPLC)
Target
Histamine Receptor
Receptor
Histamine Receptor
Chemical Name
3-(4-chlorophenyl)-1, 4, 5, 6, 7, 8-hexahydro-1-(phenylmethyl)pyrazolo[3, 4-d]azepine 2-hydroxy-1, 2, 3-propanetricarboxylate
SMILES
C1CNCCC2=C1C(=NN2CC3=CC=CC=C3)C4=CC=C(C=C4)Cl.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
Molecular Formula
C26H28ClN3O7
CAS Number
851376-05-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for JNJ-18038683 biochemical
JNJ-18038683 is a potent, selective 5-HT7 receptor antagonist with pKi of 8.19 and 8.20 for rat and human 5-HT7 in cell-based assays; decreases 5-HT (100nM)-stimulated adenylyl cyclase in rat and human 5-HT7/HEK293 cells with pKb of 8.01 and 7.99, respectively; shows 10-fold selectivity over h5-HT6 receptor, 15-fold selectivity over rat adrenergic alpha1 receptor, 14- to 25-fold selectivity over the h5-HT2 receptor subtypes, and 20-fold selectivity over h5-HT1B receptor; prolongs rapid eye movement (REM) sleep and decreases REM duration induced by citalopram in vivo. Depression Phase 2 Clinical
Product Categories/Family for JNJ-18038683 biochemical
References
1. Bonaventure P, et al. J Pharmacol Exp Ther. 2012 Aug; 342 (2):429-40.
2. Shelton J, et al. Front Behav Neurosci. 2015 Jan 15; 8:453.
2. Shelton J, et al. Front Behav Neurosci. 2015 Jan 15; 8:453.
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Product Notes
The JNJ-18038683 (Catalog #AAA3606182) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "JNJ-18038683, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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