Structure
Dorsomorphin, Inhibitor
Dorsomorphin
Purity
>98% (HPLC)
Synonyms
Dorsomorphin; BML-275; Compound C; BML275; BML 275; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
AMPK
Receptor
AMPK
Chemical Name
Pyrazolo[1, 5-a]pyrimidine, 6-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)
SMILES
C(CN1CCCCC1)OC1=CC=C(C=C1)C1=CN2N=CC(=C2N=C1)C1=CC=NC=C1
Molecular Formula
C24H25N5O
CAS Number
866405-64-3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Dorsomorphin, inhibitor
Dorsomorphin (BML-275, Compound C) is a potent, selective and reversible AMPK inhibitor with Ki of 109nM, shows no no significant activity on ZAPK, SYK, PKCtheta, PKA and JAK3; inhibits AMPK activation induced by AICAR and Metformin, also inhibits bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6); promotes cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro, induces autophagy in cancer cell lines via a mechanism independent of AMPK inhibition.
Product Categories/Family for Dorsomorphin, inhibitor
References
1. Yu PB, et al. Nat Chem Biol. 2008 Jan; 4 (1):33-41.
2. Vucicevic L, et al. Autophagy. 2011 Jan; 7 (1):40-50.
3. Diekmann U, et al. Stem Cells Dev. 2015 Jan 15; 24 (2):190-204.
4. Zhou G, et al. J Clin Invest. 2001 Oct; 108 (8):1167-74.
2. Vucicevic L, et al. Autophagy. 2011 Jan; 7 (1):40-50.
3. Diekmann U, et al. Stem Cells Dev. 2015 Jan 15; 24 (2):190-204.
4. Zhou G, et al. J Clin Invest. 2001 Oct; 108 (8):1167-74.
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Product Notes
The Dorsomorphin (Catalog #AAA3606293) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Dorsomorphin, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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