Structure
AZ82, Inhibitor
AZ82
Purity
>98% (HPLC)
Synonyms
AZ82; KIFC1 inhibitor AZ82; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 125mg/mL (222.96mM)
Target
Kinesin
Receptor
Kinesin
Chemical Name
5-methyl-N-((R)-1-oxo-1-(((R)-pyrrolidin-3-yl)amino)-3-(6-(3-(trifluoromethoxy)phenyl)pyridin-3-yl)propan-2-yl)-4-propylthiophene-2-carboxamide
SMILES
CCCC1=C(SC(=C1)C(=O)NC(CC2=CN=C(C=C2)C3=CC(=CC=C3)OC(F)(F)F)C(=O)NC4CCNC4)C
Molecular Formula
C28H31F3N4O3S
CAS Number
1449578-65-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for AZ82, inhibitor
AZ82 (KIFC1 inhibitor AZ82) is the first reported small molecule inhibitor of motor protein KIFC1 that inhibits the MT-stimulated KIFC1 enzymatic activity in an ATP-competitive and MT-noncompetitive manner with Ki of 43nM; effectively engages with the minus end-directed KIFC1 motor inside cells to reverse the monopolar spindle phenotype induced by the inhibition of the plus end-directed kinesin Eg5; causes centrosome declustering in BT-549 breast cancer cells with amplified centrosomes.
Product Categories/Family for AZ82, inhibitor
References
1. Wu J, et al. ACS Chem Biol. 2013 Oct 18; 8 (10):2201-8.
2. Yang B, et al. J Med Chem. 2014 Dec 11; 57 (23):9958-70.
2. Yang B, et al. J Med Chem. 2014 Dec 11; 57 (23):9958-70.
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Product Notes
The AZ82 (Catalog #AAA3601933) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AZ82, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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