Structure
SR31527, Inhibitor
SR31527
Purity
>98% (HPLC)
Synonyms
SR31527; SR 31527; SR-31527; inhibitor
Purity/Purification
>98% (HPLC)
Target
Kinesin
Receptor
Kinesin
Chemical Name
5-amino-3-(4-methoxyphenyl)-2-phenyl-1, 2, 4-thiadiazol-2-ium chloride
SMILES
COC1=CC=C(C2=[N+](C3=CC=CC=C3)SC(N)=N2)C=C1.[Cl-]
Molecular Formula
C15H14ClN3OS
CAS Number
311814-78-5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for SR31527, inhibitor
SR31527 is a novel allosteric Kinesin-like protein KIFC1 inhibitor that inhibits microtubule-stimulated KIFC1 ATPase activity with IC50 of 6.6uM, binds directly to KIFC1 with Kd of 25.4nM; prevents bipolar clustering of extra centrosomes in TNBC cells and significantly reducesTNBC cell colony formation and viability (MDA-MB-231, BT549 and MDA-MB-435s cells IC50=20-30uM), with less toxicity to normal fibroblasts.
Product Categories/Family for SR31527, inhibitor
References
1. Zhang W, et al. Biochem J. 2016 Apr 15; 473 (8):1027-35.
2. Yukawa M, et al. Fungal Genet Biol. 2018 Apr 21; 116:33-41.
2. Yukawa M, et al. Fungal Genet Biol. 2018 Apr 21; 116:33-41.
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Product Notes
The SR31527 (Catalog #AAA3603996) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SR31527, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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