Structure
D64131, Inhibitor
D64131
Purity
>98% (HPLC)
Synonyms
D64131; D-64131; D 64131; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
Soluble in DMSO
Target
Microtubule/Tubulin
Receptor
Tubulin polymerization
Chemical Name
(5-Methoxy-1H-indol-2-yl)phenylmethanone
SMILES
O=C(C(N1)=CC2=C1C=CC(OC)=C2)C3=CC=CC=C3
Molecular Formula
C16H13NO2
CAS Number
74588-78-6
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for D64131, inhibitor
D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53uM. The polymerization of bovine brain tubulin as well as binding of [3H] colchicine to biotinylated alphabeta-tubulin was dose-dependently inhibited by D-64131. Many Y cells display abnormal microtubule structures, such as fragmented mitotic spindles or multiple spindle poles after treatment with D-64131. Nuclear blebbing and abnormal nuclear structures typical for apoptotic cells are detectable in many cells treated with D-64131. In nude mice, D-64131 proved to be well tolerated and highly active against the human amelanoic melanoma MEXF 989 tumor xenograft. D-64131 treatment resulted in significant tumor growth inhibition during treatment.
Product Categories/Family for D64131, inhibitor
References
1.Beckers T, et al. Y Res. 2002 Jun 1; 62 (11):3113-9.
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Product Notes
The D64131 (Catalog #AAA3605843) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "D64131, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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