Structure
Monastrol, Inhibitor
Monastrol
Purity
>98% (HPLC)
Synonyms
Monastrol; (+/-)-Monastrol; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=33mg/mL
Target
Kinesin
Receptor
Eg5
Chemical Name
5-Pyrimidinecarboxylic acid, 1, 2, 3, 4-tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-, ethyl ester
SMILES
CCOC(=O)C1=C(NC(=S)NC1C2=CC(=CC=C2)O)C
Molecular Formula
C14H16N2O3S
CAS Number
329689-23-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Monastrol, inhibitor
A potent, specific, allosteric and reversible mitotic kinesin Eg5 inhibitor with IC50 of 14uM (microtubule motility inhibition); does not inhibit microtubule motility driven by conventional kinesin at 200uM; inhibits both the basal and the microtubule-stimulated ATPase activity of the Eg5 motor domain, does not compete with ATP binding to Eg5; arrests cells in mitosis with monoastral spindles, and (S)-monastrol is a more potent inhibitor of Eg5 activity in vitro and in vivo.
Product Categories/Family for Monastrol, inhibitor
References
1. Mayer TU, et al. Science. 1999 Oct 29; 286 (5441):971-4.
2. Kapoor TM, et al. J Cell Biol. 2000 Sep 4; 150 (5):975-88.
3. DeBonis S, et al. Biochemistry. 2003 Jan 21; 42 (2):338-49.
4. Maliga Z, et al. Chem Biol. 2002 Sep; 9 (9):989-96.
2. Kapoor TM, et al. J Cell Biol. 2000 Sep 4; 150 (5):975-88.
3. DeBonis S, et al. Biochemistry. 2003 Jan 21; 42 (2):338-49.
4. Maliga Z, et al. Chem Biol. 2002 Sep; 9 (9):989-96.
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Product Notes
The Monastrol (Catalog #AAA3604087) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Monastrol, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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