IFNAR1 / IFNAR recombinant protein
Recombinant Mouse IFNAR1 / IFNAR Protein (His tag)
Gene Names
Ifnar1; Ifar; Ifrc; CD118; Ifnar; Infar
Purity
> 96 % as determined by SDS-PAGE
Synonyms
IFNAR1 / IFNAR; Recombinant Mouse IFNAR1 / IFNAR Protein (His tag); Ifar; Ifnar; Ifrc; Infar; Ifnar1; IFNAR1 / IFNAR recombinant protein
Host
Human Cells
Purity/Purification
> 96 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
590
Application Notes
The recombinant mouse IFNAR1 consists of 414 amino acids and has a predicted molecular mass of 47 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rm IFNAR1 is approximately 55-60 kDa due to glycosylation.
Predicted N Terminal
Glu 27
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
Related Product Information for IFNAR1 / IFNAR recombinant protein
Background: Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.
Description: A DNA sequence encoding the extracellular domain of mouse IFNAR1 (NP_034638.2) extracellular domain (Met 1-Thr 429) was expressed, with a polyhistidine tag at the C-terminus.
Description: A DNA sequence encoding the extracellular domain of mouse IFNAR1 (NP_034638.2) extracellular domain (Met 1-Thr 429) was expressed, with a polyhistidine tag at the C-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
65,796 Da
NCBI Official Full Name
interferon alpha/beta receptor 1
NCBI Official Synonym Full Names
interferon (alpha and beta) receptor 1
NCBI Official Symbol
Ifnar1
NCBI Official Synonym Symbols
Ifar; Ifrc; CD118; Ifnar; Infar
NCBI Protein Information
interferon alpha/beta receptor 1
UniProt Protein Name
Interferon alpha/beta receptor 1
UniProt Gene Name
Ifnar1
UniProt Synonym Gene Names
Ifar; Ifnar; IFN-R-1; IFN-alpha/beta receptor 1
Uniprot Description
IFNAR1: receptor for interferons alpha and beta. Belongs to the type II cytokine family of receptors. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. Tyk2 tyrosine kinase is essential for stable cell surface expression of IFNAR1. Present in all tissues and even on the surface of most IFN-resistant cells.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 16 C3.3|16 52.98 cM
Cellular Component: integral to plasma membrane
Molecular Function: interferon receptor activity; interferon-alpha/beta binding; interferon-alpha/beta receptor activity
Biological Process: defense response to virus; interferon type I biosynthetic process; positive regulation of interferon-beta production; positive regulation of interferon-gamma production; positive regulation of interleukin-1 beta secretion; positive regulation of transcription, DNA-dependent; regulation of peptidyl-tyrosine phosphorylation; response to lipopolysaccharide; T cell activation
