Ifnar1 recombinant protein

Ifnar1, 27-429aa, Mouse, His-tag, Baculovirus

Cat. Num. AAA206457

• Gene Names: Ifnar1; Ifar; Ifrc; Ifnar; Infar
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: Ifnar1; 27-429aa; Mouse; His-tag; Baculovirus; Interferon alpha/beta receptor 1; CD118; Ifar; Ifnar; Ifrc; Infar; Ifnar1 recombinant protein

• Host: Baculovirus
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.
• Concentration: 0.5 mg/ml (determined by Absorbance at 280nm) (varies by lot)
• Sequence: ENLKPPENID VYIIDDNYTL KWSSHGESMG SVTFSAEYRT KDEAKWLKVP ECQHTTTTKC EFSLLDTNVY IKTQFRVRAE EGNSTSSWNE VDPFIPFYTA HMSPPEVRLE AEDKAILVHI SPPGQDGNMW ALEKPSFSYT IRIWQKSSSD KKTINSTYYV EKIPELLPET TYCLEVKAIH PSLKKHSNYS TVQCISTTVA NKMPVPGNLQ VDAQGKSYVL KWDYIASADV LFRAQWLPGY SKSSSGSRSD KWKPIPTCAN VQTTHCVFSQ DTVYTGTFFL HVQASEGNHT SFWSEEKFID SQKHILPPPP VITVTAMSDT LLVYVNCQDS TCDGLNYEII FWENTSNTKI SMEKDGPEFT LKNLQPLTVY CVQARVLFRA LLNKTSNFSE KLCEKTRPGS FSTLEHHHHH H
• Sequence Length: 590

• Applicable Applications for Ifnar1 recombinant protein: SDS-PAGE
• Antigen Species: Mouse
• Tag Information: His-tag
• Endotoxin Level: < 1.0 EU per 1 microgram of protein (determined by LAL method)
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for Ifnar1 recombinant protein

Ifnar1, also known as Interferon alpha/beta receptor 1, is a member of the class II cytokine receptor family of proteins. This protein forms one of the two chains of a receptor for interferons alpha and beta. It binds and activate of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Recombinant mouse Ifnar1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Categories/Family for Ifnar1 recombinant protein

Immunology; Hormones & Cytokines

References

Langer JA., et al. (2004) Cytokine Growth Factor Rev. 15:33-48.; Yan H., et al. (1996) EMBO J. 15:1064-1074.

NCBI and Uniprot Product Information

• NCBI GI #: 160358843
• NCBI GeneID: 15975
• NCBI Accession #: NP_034638
• NCBI GenBank Nucleotide #: NM_010508.2
• UniProt Accession #: P33896; Q80UJ3
• Molecular Weight: 46.8kDa (411aa) 40-57KDa (SDS-PAGE under reducing conditions.)
• NCBI Official Full Name: interferon alpha/beta receptor 1
• NCBI Official Synonym Full Names: interferon (alpha and beta) receptor 1
• NCBI Official Symbol: Ifnar1
• NCBI Official Synonym Symbols: Ifar; Ifrc; Ifnar; Infar
• NCBI Protein Information: interferon alpha/beta receptor 1
• UniProt Protein Name: Interferon alpha/beta receptor 1
• Protein Family: Interferon alpha/beta receptor
• UniProt Gene Name: Ifnar1
• UniProt Synonym Gene Names: Ifar; Ifnar; IFN-R-1; IFN-alpha/beta receptor 1

Uniprot Description

Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:1533935, PubMed:14532120, PubMed:23872679). Functions in general as heterodimer with IFNAR2 (). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:14532120). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (PubMed:23872679). Contributes to modulate the innate immune response to bacterial lipopolysaccharide (PubMed:23872679).