Human Interferon alpha/betaReceptor, IFN-alpha/betaR ELISA Kit | IFN-alpha/betaR elisa kit

Human Interferon alpha/betaReceptor, IFN-alpha/betaR ELISA Kit

Cat. Num. AAA163523

• Gene Names: Ifnar1; Ifar; Ifrc; Ifnar; Infar
• Reactivity: Human
• Synonyms: Interferon alpha/betaReceptor; IFN-alpha/betaR; Human Interferon alpha/betaReceptor; IFN-alpha/betaR ELISA Kit; IFN-alpha/betaR elisa kit

• Reactivity: Human
• Sequence Length: 590

• Samples: Serum, plasma, cell culture supernates, cell lysates, tissue homogenates
• Assay Type: Quantitative Sandwich
• Detection Range: 5pg/ml - 2000pg/ml
• Sensitivity: 2.51pg/ml
• Intra-Assay: CV<8%
• Inter-Assay: CV<10%
• Preparation and Storage: Store at 2 to 8 degree C for 6 months.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for IFN-alpha/betaR elisa kit

Intended Uses: This sandwich kit is for the accurate quantitative detection of human Interferon Receptor (also known as IFN-AR) in serum, plasma, cell culture supernates, cell lysates, tissue homogenates.

Principles of the Assay: This kit is an Enzyme-Linked Immunosorbent Assay (ELISA). The plate has been pre-coated with human IFN-AR antibody. IFN-AR present in the sample is added and binds to antibodies coated on the wells. And then biotinylated human IFN-AR Antibody is added and binds to IFN-AR in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated IFN-AR antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of human IFN-AR. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.

NCBI and Uniprot Product Information

• NCBI GI #: 160358843
• NCBI GeneID: 15975
• NCBI Accession #: NP_034638.2
• NCBI GenBank Nucleotide #: NM_010508.2
• UniProt Accession #: P33896; Q80UJ3
• Molecular Weight: 65,796 Da
• NCBI Official Full Name: interferon alpha/beta receptor 1
• NCBI Official Synonym Full Names: interferon (alpha and beta) receptor 1
• NCBI Official Symbol: Ifnar1
• NCBI Official Synonym Symbols: Ifar; Ifrc; Ifnar; Infar
• NCBI Protein Information: interferon alpha/beta receptor 1
• UniProt Protein Name: Interferon alpha/beta receptor 1
• UniProt Gene Name: Ifnar1
• UniProt Synonym Gene Names: Ifar; Ifnar; IFN-R-1; IFN-alpha/beta receptor 1

Uniprot Description

Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:1533935, PubMed:14532120, PubMed:23872679). Functions in general as heterodimer with IFNAR2 (). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:14532120). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (PubMed:23872679). Contributes to modulate the innate immune response to bacterial lipopolysaccharide (PubMed:23872679).