IFNAR1 Protein Recombinant Protein | IFNAR1 recombinant protein

Recombinant Mouse IFNAR1 Protein (His Tag)

Cat. Num. AAA2569312

• Gene Names: Ifnar1; Ifar; Ifrc; CD118; Ifnar; Infar
• Purity: >85% as determined by reducing SDS-PAGE
• Synonyms: IFNAR1 Protein; Recombinant Mouse IFNAR1 Protein (His Tag); Interferon alpha/beta receptor 1; IFN-R-1 IFN-alpha/beta receptor 1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; CRF2-1; Type I interferon receptor 1; IFNAR; IFNAR1 recombinant protein

• Host: E Coli
• Purity/Purification: >85% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4
• Sequence: Glu27-Cyc284

• Species: Mouse
• Tag: N-His
• Protein Construction: A DNA sequence encoding the Mouse IFNAR1 (P33896-1)(Glu27-Cyc284) was expressed with a polyhistidine tag at the N-terminus.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

SDS-Page

Related Product Information for IFNAR1 recombinant protein

Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves. Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.

NCBI and Uniprot Product Information

• NCBI GI #: 160358843
• NCBI GeneID: 15975
• NCBI Accession #: NP_034638.2
• NCBI GenBank Nucleotide #: NM_010508.2
• UniProt Accession #: P33896; Q80UJ3
• Molecular Weight: 65,796 Da
• NCBI Official Full Name: interferon alpha/beta receptor 1
• NCBI Official Synonym Full Names: interferon (alpha and beta) receptor 1
• NCBI Official Symbol: Ifnar1
• NCBI Official Synonym Symbols: Ifar; Ifrc; CD118; Ifnar; Infar
• NCBI Protein Information: interferon alpha/beta receptor 1
• UniProt Protein Name: Interferon alpha/beta receptor 1
• Protein Family: Interferon alpha/beta receptor
• UniProt Gene Name: Ifnar1
• UniProt Synonym Gene Names: Ifar; Ifnar; IFN-R-1; IFN-alpha/beta receptor 1

Uniprot Description

IFNAR1: receptor for interferons alpha and beta. Belongs to the type II cytokine family of receptors. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. Tyk2 tyrosine kinase is essential for stable cell surface expression of IFNAR1. Present in all tissues and even on the surface of most IFN-resistant cells.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 16 C3.3|16 52.98 cM

Cellular Component: integral to plasma membrane

Molecular Function: interferon receptor activity; interferon-alpha/beta binding; interferon-alpha/beta receptor activity

Biological Process: defense response to virus; interferon type I biosynthetic process; positive regulation of interferon-beta production; positive regulation of interferon-gamma production; positive regulation of interleukin-1 beta secretion; positive regulation of transcription, DNA-dependent; regulation of peptidyl-tyrosine phosphorylation; response to lipopolysaccharide; T cell activation