Testing Data
anti-Human Pin-1 Antibody | anti-Pin-1 antibody
Pin-1, Chicken
Reactivity
Human
Applications
Immunocytochemistry, Immunofluorescence, Western Blot
Synonyms
Pin-1; Chicken; anti-Pin-1 antibody
Reactivity
Human
Form/Format
Whole serum - Liquid
Applicable Applications for anti-Pin-1 antibody
Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB)
Type Info
Chicken IgY
Immunogen
Recombinant full length Pin-1 purified from E Coli.
Testing Data
Testing Data
Testing Data
(Image: Western blot of whole HeLa cell homogenate stained with Pin1, at dilution of 1:10,000. A prominent band running with an apparent SDS-PAGE molecular weight of ~21kDa corresponds to Pin1.)
Testing Data
(Image: Western blot of whole HeLa cell homogenate stained with Pin1, at dilution of 1:10,000. A prominent band running with an apparent SDS-PAGE molecular weight of ~21kDa corresponds to Pin1.)
Related Product Information for anti-Pin-1 antibody
Pin-1 is a the peptidylprolyl cis/trans isomerase enzyme which is responsible, as its name suggests, for flipping the proline ring from the cis to the trans conformation.
Pin1 has been implicated in tau pathologies that underlie Alzheimer's Disease. Pin1 binds to tau phosphorylated specifically on the Thr231-Pro site and induces conformational changes in tau. Such conformational changes can directly restore the ability of phosphorylated Tau to bind microtubules and promote microtubule assembly and/or facilitate tau dephosphorylation. Pin1 expression inversely correlates with the predicted neuronal vulnerability in normally aged brain and also with actual neurofibrillary degeneration in AD brain. Pin1 could be pivotal for maintainance of normal neuronal function and preventing age-dependent neurodegeneration. It is also heavily upregulated in tumor cells, so that antibodies to this protein can be used as tumor markers.
Pin1 has been implicated in tau pathologies that underlie Alzheimer's Disease. Pin1 binds to tau phosphorylated specifically on the Thr231-Pro site and induces conformational changes in tau. Such conformational changes can directly restore the ability of phosphorylated Tau to bind microtubules and promote microtubule assembly and/or facilitate tau dephosphorylation. Pin1 expression inversely correlates with the predicted neuronal vulnerability in normally aged brain and also with actual neurofibrillary degeneration in AD brain. Pin1 could be pivotal for maintainance of normal neuronal function and preventing age-dependent neurodegeneration. It is also heavily upregulated in tumor cells, so that antibodies to this protein can be used as tumor markers.
Product Categories/Family for anti-Pin-1 antibody
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Product Notes
The Pin-1 (Catalog #AAA555396) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Pin-1, Chicken reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Pin-1 can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB). Researchers should empirically determine the suitability of the Pin-1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Pin-1, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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