Testing Data
(Image: Human cerebellar cortex fixed in formalin, embedded in paraffin and stained with Mouse Monoclonal NF-H using the ABC (avidin biotin conjugate) method. The section was counterstained with heamatoxylin-eosin (blue). MCA-NAP4 stains prominent basket cell axons surrounding the large Purkinje neurons. Granule cell layer at bottom of image, molecular layer at top. Protocol on Data-sheet.)
NF-H Antibody | anti-NF-H antibody
NF-H, Monoclonal Antibody, Mouse
Testing Data
(Image: Human cerebellar cortex fixed in formalin, embedded in paraffin and stained with Mouse Monoclonal NF-H using the ABC (avidin biotin conjugate) method. The section was counterstained with heamatoxylin-eosin (blue). MCA-NAP4 stains prominent basket cell axons surrounding the large Purkinje neurons. Granule cell layer at bottom of image, molecular layer at top. Protocol on Data-sheet.)
Testing Data
(Image: Human cerebellar cortex fixed in formalin, embedded in paraffin and stained with Mouse Monoclonal NF-H using the ABC (avidin biotin conjugate) method. The section was counterstained with heamatoxylin-eosin (blue). MCA-NAP4 stains prominent basket cell axons surrounding the large Purkinje neurons. Granule cell layer at bottom of image, molecular layer at top. Protocol on Data-sheet.)
Testing Data
(Image: Rat spinal cord homogenate showing the major intermediate filament proteins of the nervous system (lane 1). The remaining lanes show blots of this material stainted with various antibodies including: Mouse Monoclonal NF-H (Lane 2), NF-M, NF-L, NF66 and GFAP. Protocol on Data-sheet.)
Testing Data
(Image: Rat spinal cord homogenate showing the major intermediate filament proteins of the nervous system (lane 1). The remaining lanes show blots of this material stainted with various antibodies including: Mouse Monoclonal NF-H (Lane 2), NF-M, NF-L, NF66 and GFAP. Protocol on Data-sheet.)
NCBI and Uniprot Product Information
NCBI Description
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq, Oct 2008]
Uniprot Description
NFH: Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins. Belongs to the intermediate filament family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 22q12.2
Cellular Component: mitochondrion; axon; cytoplasm; neurofilament
Molecular Function: protein binding, bridging; dynein binding; structural constituent of cytoskeleton; kinesin binding; microtubule binding; structural molecule activity; protein kinase binding
Biological Process: neurofilament bundle assembly; axonogenesis; cell projection biogenesis; microtubule cytoskeleton organization and biogenesis; peripheral nervous system neuron axonogenesis
Disease: Amyotrophic Lateral Sclerosis 1
Research Articles on NF-H
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Product Notes
The NF-H nefh (Catalog #AAA555039) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The NF-H, Monoclonal Antibody, Mouse reacts with Bovine, Cat, Chicken, Dog, Equine, Guinea Pig, Human, Mouse, Porcine, Primate, Rat, Rabbit and may cross-react with other species as described in the data sheet. AAA Biotech's NF-H can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB). Researchers should empirically determine the suitability of the NF-H nefh for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NF-H, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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