anti-Human Casein Kinase 1 alpha Antibody | anti-CSNK1A1 antibody

Casein Kinase 1 alpha, Antiserum, Chicken

Cat. Num. AAA555397

• Gene Names: CSNK1A1; CK1; CK1a; CKIa; HLCDGP1; PRO2975; HEL-S-77p
• Reactivity: Human
• Applications: Immunocytochemistry, Immunofluorescence, Western Blot
• Synonyms: Casein Kinase 1 alpha; Antiserum; Chicken; anti-CSNK1A1 antibody

• Reactivity: Human
• Form/Format: Whole serum - Liquid
• Sequence Length: 365

• Applicable Applications for anti-CSNK1A1 antibody: Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB)
• Type Info: Chicken IgY
• Immunogen: Human Casein Kinase 1 alpha protein.

Testing Data

(Image: HeLa cells stained with chicken casein kinase 1 alpha antibody (red) and our panspecific mouse monoclonal antibody to nuclear pore complexes 39C7-a Panspecific Nuclear Pore Complex Marker. Casein kinase 1 alpha has a particulate distribution both in the nucleus and the cytoplasm. Blue is the Hoeschst DNA stain.)

Related Product Information for anti-CSNK1A1 antibody

The CKI family consists of several different genes, divided in alpha, beta, gamma, delta and epsilon, some of which are encoded by more than one gene. The single mammalian CK1 alpha gene can generate four different proteins by alterate transcription. CK1a was raised against the shortest of these proteins, and will therefore bind to all CK1 isotypes. The CK1 alpha proteins are involved in the control of protein degradation, and phosphorylate acidic regions of their substrate molecules. Typically the target ser/thr residues closely C-terminal to two or three aspartic or glutamic acid residues. Alternately, phosphorylation on residues 3 or 4 amino acids N-terminal to a ser/thr residue can also favor CKI phosphorylation. This means that CKI family enzymes often phosphorylate one or more ser/thr residues C-terminal to a phosphorylation site generated by the activity of another protein kinase.

Product Categories/Family for anti-CSNK1A1 antibody

Antibodies; Neurodegenerative Disease; Casein Kinase 1 alpha

NCBI and Uniprot Product Information

• NCBI GI #: 68303575
• NCBI GeneID: 1452
• NCBI Accession #: NP_001020276.1
• NCBI GenBank Nucleotide #: NM_001025105.2
• Molecular Weight: 37,567 Da
• NCBI Official Full Name: casein kinase I isoform alpha isoform 1
• NCBI Official Synonym Full Names: casein kinase 1 alpha 1
• NCBI Official Symbol: CSNK1A1
• NCBI Official Synonym Symbols: CK1; CK1a; CKIa; HLCDGP1; PRO2975; HEL-S-77p
• NCBI Protein Information: casein kinase I isoform alpha
• UniProt Protein Name: Casein kinase I isoform alpha
• Protein Family: Casein kinase
• UniProt Gene Name: CSNK1A1
• UniProt Synonym Gene Names: CKI-alpha
• UniProt Entry Name: KC1A_HUMAN

Uniprot Description

CK1A: an ubiquitous protein kinase of the CK1 family. Participates in Wnt signaling. Phosphorylates beta catenin, marking it for beta-TRCp-mediated ubiquitinylation and proteasomal degradation.

Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CK1; Kinase, protein; CK1 group; CK1 family

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: centrosome; membrane; cytoplasm; nuclear speck; mRNA cleavage and polyadenylation specificity factor complex; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding; protein kinase activity

Biological Process: mitosis; regulation of cell shape; peptidyl-serine phosphorylation; Wnt receptor signaling pathway; cell surface receptor linked signal transduction; cell division; signal transduction; protein amino acid phosphorylation; phagocytosis