Testing Data
(Image: Immunocytochemistry of a mixed neuron/glial culture from newborn rat brain stained with Coronin 1a (green) at a dilution of 1:10,000 and chicken polyclonal Vimentin (1:5,000). Blue is nuclear DNA counter stain. Glial cells and fibroblasts stain with vimentin, while microglia alone stain strongly and specifically for Coronin 1a, which can therefore be used as a robust marker of this important cell type. Protocol on data-sheet)
Coronin 1a/p57 Antibody | anti-CORO1A antibody
Coronin 1a/p57, Antiserum, Rabbit
Testing Data
(Image: Immunocytochemistry of a mixed neuron/glial culture from newborn rat brain stained with Coronin 1a (green) at a dilution of 1:10,000 and chicken polyclonal Vimentin (1:5,000). Blue is nuclear DNA counter stain. Glial cells and fibroblasts stain with vimentin, while microglia alone stain strongly and specifically for Coronin 1a, which can therefore be used as a robust marker of this important cell type. Protocol on data-sheet)
Testing Data
(Image: Immunocytochemistry of a mixed neuron/glial culture from newborn rat brain stained with Coronin 1a (green) at a dilution of 1:10,000 and chicken polyclonal Vimentin (1:5,000). Blue is nuclear DNA counter stain. Glial cells and fibroblasts stain with vimentin, while microglia alone stain strongly and specifically for Coronin 1a, which can therefore be used as a robust marker of this important cell type. Protocol on data-sheet)
Testing Data
(Image: Western blot of HL60 Cell extract stained with Coronin 1a, at dilution of 1:10,000. A prominent band running with an apparent SDS-PAGE molecular weight of ~57kDa corresponds to Coronin 1a. Numbers represent positions of molecular weight standards in kDa.)
Testing Data
(Image: Western blot of HL60 Cell extract stained with Coronin 1a, at dilution of 1:10,000. A prominent band running with an apparent SDS-PAGE molecular weight of ~57kDa corresponds to Coronin 1a. Numbers represent positions of molecular weight standards in kDa.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]
Uniprot Description
coronin 1A: May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria- infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. Belongs to the WD repeat coronin family.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: cortical actin cytoskeleton; protein complex; early endosome; immunological synapse; actin filament; intercellular junction; phagocytic vesicle; phagocytic vesicle membrane; membrane; lamellipodium; axon; cytoplasm; plasma membrane; nucleus; phagocytic cup
Molecular Function: protein C-terminus binding; actin filament binding; protein binding; protein homodimerization activity; cytoskeletal protein binding; phosphoinositide 3-kinase binding
Biological Process: negative regulation of vesicle fusion; leukocyte chemotaxis; actin filament organization; phagocytosis; cell-substrate adhesion; regulation of release of sequestered calcium ion into cytosol; uropod organization and biogenesis; phagolysosome formation; regulation of cell shape; regulation of actin filament polymerization; positive chemotaxis; homeostasis of number of cells within a tissue; calcium ion transport; negative regulation of actin nucleation; innate immune response; positive regulation of T cell proliferation; T cell homeostasis; negative regulation of neuron apoptosis; cell motility; actin cytoskeleton organization and biogenesis; positive regulation of cell migration
Disease: Immunodeficiency 8
Research Articles on CORO1A
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Product Notes
The CORO1A coro1a (Catalog #AAA555195) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Coronin 1a/p57, Antiserum, Rabbit reacts with Cat, Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Coronin 1a/p57 can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB). Researchers should empirically determine the suitability of the CORO1A coro1a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Coronin 1a/p57, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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