SDS-Page
Insulin R/CD220 Active Protein | IRS1 active protein
Human CellExp Insulin R/CD220, Human Recombinant
Purity
>90% as determined by SDS-PAGE
Synonyms
Insulin R/CD220; Human CellExp Insulin R/CD220; Human Recombinant; INSR; Insulin receptor; IR; CD220; IRS1 active protein
Host
HEK293 cells
Purity/Purification
>90% as determined by SDS-PAGE
Form/Format
Lyophilized powder. Lyophilized from 0.22um filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
Sequence
aaHis28-Lys944
Gene Source
Human
Endotoxin
Less than 1.0 EU per ug by the LAL method.
Biological Activity
Immobilized Human Insulin R (28-944), His Tag at 5 ug/mL (100 uL/well) can bind Human IGF-II, Fc Tag with a linear range of 0.078-1.25 ug/mL
Reconstitution Instruction
Reconstitute in sterile deionized water, pH 7.4 to a concentration of 50 ug/ml. Do not vortex. It is recommended to store at store at -20 degree C.
Preparation and Storage
Store at -20 degree C
Centrifuge the vial prior to opening.
Shelf life: ~12 months
Centrifuge the vial prior to opening.
Shelf life: ~12 months
SDS-Page
SDS-Page
Testing Data
Testing Data
Testing Data
Testing Data
Related Product Information for IRS1 active protein
Insulin receptor (INSR) is also known as CD antigen CD220, which can be cleaved into the following 2 chains: Insulin receptor subunit alpha and Insulin receptor subunit beta. INSR is a tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains carry the insulin-binding regions, while the beta chains carry the kinase domain. Forms a hybrid receptor with IGF1R, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short of INSR has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, INSR binds IGF1. Receptor tyrosine kinase which mediates the pleiotropic actions of insulin
Product Categories/Family for IRS1 active protein
NCBI and Uniprot Product Information
NCBI GeneID
UniProt Accession #
Molecular Weight
106.5kDa (His 28 - Lys 944)
Protein Family
Similar Products
Product Notes
The IRS1 (Catalog #AAA8400001) is an Active Protein produced from HEK293 cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: aaHis28-Ly s944. It is sometimes possible for the material contained within the vial of "Insulin R/CD220, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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