ICOSLG/B7-H2/CD275 Active Protein | ICOSLG active protein

Human CellExp ICOSLG/B7-H2/CD275, Fc Tag, Human Recombinant

Cat. Num. AAA8400008

• Purity: >95% as determined by SDS-PAGE.
• Synonyms: ICOSLG/B7-H2/CD275; Human CellExp ICOSLG/B7-H2/CD275; Fc Tag; Human Recombinant; ICOSLG; B7-H2; B7H2; B7RP-1; B7RP1; CD275; GL50; ICOS-L; ICOSL; LICOS; ICOS ligand; ICOSLG active protein

• Host: HEK293 cells
• Purity/Purification: >95% as determined by SDS-PAGE.
• Form/Format: Lyophilized powder. Lyophilized from 0.22um filtered solution in 50mM Tris, 100mM Glycine, 25mM Arginine, 150mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.
• Sequence: aaAsp19-Ser258

• Gene Source: Human
• Endotoxin: Less than 1.0 EU per ug by the LAL method.
• Biological Activity: Immobilized Human ICOS (C136S, C137S) at 5 ug/mL (100 uL/well) can bind Human B7-H2, Fc Tag with a linear range of 0.3-5 ng/mL
• Reconstitution Instruction: Reconstitute in sterile deionized water to a concentration of 100 ug/ml. Do not vortex. It is recommended to store at store at -20 degree C.
• Tag Note: This protein carries a human IgG1 Fc tag at the C-terminus.
• Preparation and Storage: Store at -20 degree C; Centrifuge the vial prior to opening.; Shelf life: ~12 months

SDS-Page

Testing Data

Related Product Information for ICOSLG active protein

ICOS ligand (ICOSLG) is also known as B7 homolog 2 (B7-H2), B7-related protein 1 (B7RP-1) and CD antigen CD275, which belongs to the immunoglobulin superfamily and BTN/MOG family. ICOSLG contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. Isoform 1 is widely expressed, while isoform 2 is detected only in lymph nodes, leukocytes and spleen. B7-H2 is ligand for the T-cell-specific cell surface receptor ICOS. B7-H2 acts as a costimulatory signal for T-cell proliferation and cytokine secretion and induces also B-cell proliferation and differentiation into plasma cells. B7-H2 could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. Ligand for the T-cell-specific cell surface receptor ICOS

Product Categories/Family for ICOSLG active protein

Proteins; Enzymes; Cytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z); CDs; Human cell expressed recombinant proteins

NCBI and Uniprot Product Information

• NCBI GI #: 19855066
• NCBI GeneID: 102723996
• UniProt Accession #: O75144; Q9HD18; Q9NRQ1; A8MUZ1
• Molecular Weight: 20,120 Da
• NCBI Official Full Name: ICOS ligand
• NCBI Official Symbol: LOC102723996
• NCBI Protein Information: ICOS ligand
• UniProt Protein Name: ICOS ligand
• Protein Family: ICOS ligand
• UniProt Gene Name: ICOSLG
• UniProt Synonym Gene Names: B7H2; B7RP1; ICOSL; KIAA0653; B7-H2; B7RP-1

Uniprot Description

Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function ().