SDS-Page
ICOSLG/B7-H2/CD275 Active Protein | ICOSLG active protein
Human CellExp ICOSLG/B7-H2/CD275, Fc Tag, Human Recombinant
Purity
>95% as determined by SDS-PAGE.
Synonyms
ICOSLG/B7-H2/CD275; Human CellExp ICOSLG/B7-H2/CD275; Fc Tag; Human Recombinant; ICOSLG; B7-H2; B7H2; B7RP-1; B7RP1; CD275; GL50; ICOS-L; ICOSL; LICOS; ICOS ligand; ICOSLG active protein
Host
HEK293 cells
Purity/Purification
>95% as determined by SDS-PAGE.
Form/Format
Lyophilized powder. Lyophilized from 0.22um filtered solution in 50mM Tris, 100mM Glycine, 25mM Arginine, 150mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.
Sequence
aaAsp19-Ser258
Gene Source
Human
Endotoxin
Less than 1.0 EU per ug by the LAL method.
Biological Activity
Immobilized Human ICOS (C136S, C137S) at 5 ug/mL (100 uL/well) can bind Human B7-H2, Fc Tag with a linear range of 0.3-5 ng/mL
Reconstitution Instruction
Reconstitute in sterile deionized water to a concentration of 100 ug/ml. Do not vortex. It is recommended to store at store at -20 degree C.
Tag Note
This protein carries a human IgG1 Fc tag at the C-terminus.
Preparation and Storage
Store at -20 degree C
Centrifuge the vial prior to opening.
Shelf life: ~12 months
Centrifuge the vial prior to opening.
Shelf life: ~12 months
SDS-Page
SDS-Page
Testing Data
Testing Data
Related Product Information for ICOSLG active protein
ICOS ligand (ICOSLG) is also known as B7 homolog 2 (B7-H2), B7-related protein 1 (B7RP-1) and CD antigen CD275, which belongs to the immunoglobulin superfamily and BTN/MOG family. ICOSLG contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. Isoform 1 is widely expressed, while isoform 2 is detected only in lymph nodes, leukocytes and spleen. B7-H2 is ligand for the T-cell-specific cell surface receptor ICOS. B7-H2 acts as a costimulatory signal for T-cell proliferation and cytokine secretion and induces also B-cell proliferation and differentiation into plasma cells. B7-H2 could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. Ligand for the T-cell-specific cell surface receptor ICOS
Product Categories/Family for ICOSLG active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
20,120 Da
NCBI Official Full Name
ICOS ligand
NCBI Official Symbol
LOC102723996
NCBI Protein Information
ICOS ligand
UniProt Protein Name
ICOS ligand
Protein Family
UniProt Gene Name
ICOSLG
UniProt Synonym Gene Names
B7H2; B7RP1; ICOSL; KIAA0653; B7-H2; B7RP-1
Uniprot Description
Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function ().
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Product Notes
The ICOSLG icoslg (Catalog #AAA8400008) is an Active Protein produced from HEK293 cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: aaAsp19-Se r258. It is sometimes possible for the material contained within the vial of "ICOSLG/B7-H2/CD275, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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