DNAM-1/CD226 Active Protein | CD226 active protein

Human CellExp DNAM-1/CD226, Fc Tag, Human Recombinant

Cat. Num. AAA8400117

• Gene Names: CD226; PTA1; DNAM1; DNAM-1; TLiSA1
• Purity: >95% by SDS-PAGE
• Synonyms: DNAM-1/CD226; Human CellExp DNAM-1/CD226; Fc Tag; Human Recombinant; DNAM1; CD226; PTA1; CD226 active protein

• Host: HEK293 cells
• Purity/Purification: >95% by SDS-PAGE
• Form/Format: Lyophilized powder. Lyophilized from 0.22um filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization
• Sequence: aaGlu19-Asn247

• Gene Source: Human
• Endotoxin: Less than 1.0 EU per ug by the LAL method.
• Biological Activity: Immobilized Rhesus macaque CD155 at 5 ug/mL (100 uL/well) can bind Human DNAM-1, Fc Tag with a linear range of 2-31 ng/mL
• Reconstitution Instruction: Reconstitute in sterile deionized water to the desired protein concentration.
• Tag Note: This protein carries a human IgG1 Fc tag at the C-terminus.
• Preparation and Storage: Store at -20 degree C; Centrifuge the vial prior to opening.; Shelf life: ~12 months

SDS-Page

Testing Data

Testing Data

Related Product Information for CD226 active protein

DNAX accessory molecule 1 (DNAM-1), a single-pass type I membrane protein, is also known as CD226 antigen and platelet and T cell activation antigen 1 (PTA1), which contains 2 Ig-like C2-type (immunoglobulin-like) domains. DNAM-1 is a ~65 kDa glycoprotein expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. DNAM-1 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155, and cross-linking DNAM-1 with antibodies causes cellular activation. Furthermore, DNAM-1 can interact with PVR and PVRL2. Mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells

Product Categories/Family for CD226 active protein

Proteins; Enzymes; Proteins & Enzymes (A-Z); Cytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z); Cancer Research; Growth Factors; FGFs; Human cell expressed recombinant proteins

NCBI and Uniprot Product Information

• NCBI GI #: 171460997
• NCBI GeneID: 10666
• NCBI Accession #: NP_006557
• NCBI GenBank Nucleotide #: NM_006566.3
• UniProt Accession #: Q15762; B2R818
• Molecular Weight: 29.4 kDa (259aa)
• NCBI Official Full Name: CD226 antigen isoform a
• NCBI Official Synonym Full Names: CD226 molecule
• NCBI Official Symbol: CD226
• NCBI Official Synonym Symbols: PTA1; DNAM1; DNAM-1; TLiSA1
• NCBI Protein Information: CD226 antigen
• UniProt Protein Name: CD226 antigen
• Protein Family: CD226 antigen
• UniProt Gene Name: CD226
• UniProt Synonym Gene Names: DNAM1; DNAM-1
• UniProt Entry Name: CD226_HUMAN

NCBI Description

This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Uniprot Description

DNAM-1: Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell.

Protein type: Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 18q22.3

Cellular Component: cell surface; integral to plasma membrane; plasma membrane; external side of plasma membrane; lipid raft

Molecular Function: integrin binding; protein binding; cell adhesion molecule binding; protein kinase binding

Biological Process: regulation of immune response; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; positive regulation of immunoglobulin mediated immune response; cytokine production; cell recognition; cell adhesion; positive regulation of natural killer cell mediated cytotoxicity; signal transduction; positive regulation of mast cell activation